116199-41-8Relevant academic research and scientific papers
Preparation of Enantioenriched Alkylcarbastannatranes via Nucleophilic Inversion of Alkyl Mesylates for Use in Stereospecific Cross-Coupling Reactions
Ralph, Glenn,Biscoe, Mark R.
, p. 3912 - 3915 (2019)
We report the preparation of enantioenriched secondary alkylcarbastannatranes via a stereoinvertive SN2 reaction of enantioenriched alkyl mesylates and carbastannatranyl anion equivalents. Using this process, enantioenriched secondary alcohols may be converted into highly enantioenriched alkylcarbastannatranes, which are useful in stereospecific cross-coupling reactions.
Convenient route to secondary sulfinates: Application to the stereospecific synthesis of α- C -chiral sulfonamides
Gribble, Michael W.,Houze, Jonathan B.,Johnson, Michael G.,Paras, Nick A.
, p. 6248 - 6251 (2014)
A convenient synthesis of α-chiral sulfinates from readily available precursors has been accomplished via the corresponding heterocyclic thioethers and sulfones. Treatment of the sulfinates with hydroxylamine sulfonate in aqueous solution provides α-C-chiral primary sulfonamides in good yield (14 examples) with retention of stereochemical purity.
Cyclopropenone catalyzed substitution of alcohols with mesylate ion
Nacsa, Eric D.,Lambert, Tristan H.
supporting information, p. 38 - 41 (2013/03/28)
The cyclopropenone catalyzed nucleophilic substitution of alcohols by methanesulfonate ion with inversion of configuration is described. This work provides an alternative to the Mitsunobu reaction that avoids the use of azodicarboxylates and generation of hydrazine and phosphine oxide byproducts. This transformation is shown to be compatible with a range of functionality. A cyclopropenone scavenge strategy is demonstrated to aid purification.
