116236-98-7Relevant academic research and scientific papers
SYNTHESIS OF PUNAGLANDIN 4 BY MEANS OF ENZYMATIC RESOLUTION OF THE KEY CHLOROCYCLOPENTENE DERIVATIVE
Mori, Kenji,Takeuchi, Tadashi
, p. 333 - 342 (1988)
Punaglandin 4, a chlorinated marine prostanoid, was synthesized starting from two chiral building blocks, (+)-tartaric acid and (1S, 4R)-(-)-4-t-butyldimethylsilyloxy-3-chloro-2-cyclopenten-1-ol, which was prepared by asymmetric hydrolysis of the correspo
CYCLIC AMINE COMPOUND
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Page/Page column 147, (2009/04/23)
The present invention provides an excellent antihypertensive medicament. The medicament of the present invention comprises a compound having the general formula (I) and the like: [wherein R1: H, substitutable alkyl, substitutable alkenyl, substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; R2: H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R3, R4; H, substitutable alkyl, substitutable alkenyl, substitutable cycloalkyl or the like; R5, R6: H, substitutable alkyl, substitutable cycloalkyl, substitutable alkoxy or the like; R7, R8: H, substitutable alkyl, substitutable cycloalkyl or the like; X: the formula (II) or the like; A: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like; Y: a single bond, substitutable alkylene, substitutable alkenylene, -(CH2)a-X1-(CH2)b- (X1: the formula -NH-, -O- or the like; a, b: 0-5) or the like; B: substitutable cyclic hydrocarbon, substitutable heterocyclyl or the like].
