SYNTHESIS OF PUNAGLANDIN 4 BY MEANS OF ENZYMATIC RESOLUTION OF THE KEY CHLOROCYCLOPENTENE DERIVATIVE

Article abstract of DOI:10.1016/S0040-4020(01)85825-7

Punaglandin 4, a chlorinated marine prostanoid, was synthesized starting from two chiral building blocks, (+)-tartaric acid and (1S, 4R)-(-)-4-t-butyldimethylsilyloxy-3-chloro-2-cyclopenten-1-ol, which was prepared by asymmetric hydrolysis of the correspo