116247-98-4

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-PIPERIDIN-4-ONE
• Synonyms: 1-(4-FLUORO-PHENYL)-PIPERIDIN-4-ONE;1-N-(4'-FLUOROPHENYL)-PIPERIDIN-4-ONE;CHEMBRDG-BB 4000326;1-(4-Fluorophenyl)piperidine-4-one;1-(4-fluorophenyl)piperidin-4-one(SALTDATA: FREE);N-(4-Fluorophenyl)-4-oxo-piperidine
• CAS NO: 116247-98-4
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.22
• Product Categories: CHIRAL CHEMICALS
• Mol File: 116247-98-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 329.8°C at 760 mmHg
• Flash Point: 153.3°C
• Appearance: /
• Density: 1.189g/cm³
• Vapor Pressure: 0.000173mmHg at 25°C
• Refractive Index: 1.543
• PKA: 5.26±0.40(Predicted)
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-PIPERIDIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-PIPERIDIN-4-ONE(116247-98-4)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-PIPERIDIN-4-ONE(116247-98-4)

Safety Data

• Hazardous Substances Data: 116247-98-4(Hazardous Substances Data)

Usage

General Description

1-(4-fluoro-phenyl)-piperidin-4-one is a chemical compound with the molecular formula C11H12FNO. It is a piperidinone derivative that contains a piperidine ring with a fluorophenyl group attached to it. 1-(4-FLUORO-PHENYL)-PIPERIDIN-4-ONE is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. It has also been studied for its potential pharmacological properties, including its role as a dopamine receptor antagonist. Additionally, 1-(4-fluoro-phenyl)-piperidin-4-one has been investigated for its potential applications in the treatment of neurological disorders and as a building block in the creation of new chemical entities.

InChI:InChI=1/C11H12FNO/c12-9-1-3-10(4-2-9)13-7-5-11(14)6-8-13/h1-4H,5-8H2

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 3592-25-4 1,5-dichloropentan-3-one 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1244027-32-4 1-(4-fluorophenyl)-6'-(5-methyl-1H-pyrazol-4-yl)-1'H-spiro[piperidine-4,2'-thieno[3,2-d]pyrimidin]-4'(3'H)-one 
• 1259380-41-0 1-(4-fluorophenyl)-7'-methoxy-5'H-spiro[piperidine-4,4'-pyrrolo[1,2-a]quinoxaline] hydrochloride 
• 1192165-71-1 [1-(4-fluorophenyl)-4-methylpiperidin-4-yl]acetonitrile 
• 1192165-70-0 ethyl cyano[1-(4-fluorophenyl)-4-methylpiperidin-4-yl]acetate 
• 1235971-77-3 1-(4-fluoro-benzyl)-4-[1-(4-fluoro-phenyl)-piperidin-4-yl]-piperazine 
• 1070894-63-1 8-(4-fluorophenyl)-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one 
• 1160787-01-8 methyl 2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate 

Relevant articles and documents

Effect of through-bond interaction on conformation and structure in rod-shaped donor - acceptor systems: Part 1. Crystal structures of five N-arylpiperidin-4-one derivatives

The crystal structures of five N-arylpiperidin-4-one derivatives 2P2, 3P2, 5P2, 1P3, and 2P3 are presented (Fig. 2 and Tables 1-5) and discussed together with the derivatives 1P2 and 4P2 published previously. In all but one structure, 1P2, the aryl group is in an equatorial position. The piperidine ring adopts a normal chair conformation. In 1P2, the piperidine ring central C-C bonds are significantly elongated, which is consistent with the idea that through-bond interaction is more pronounced in the axial conformation. Through-bond interaction also influences the pyramidalization at the piperidine C(4)-atom in such a way that a strong interaction is directing the ethylene C-atom C(9) into the axial direction.

5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND

The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R1 represents a group —X-Q1, X-Q1-Y-Q2 or X-Q1-Y-Q2-Z-Q3, X represents a single bond, —CH2— or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH2—, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR11R12— or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].

Synthesis and exploratory photophysical investigation of donor-bridge-acceptor systems derived from N-substituted 4-piperidones

We report a two-step synthesis for N-aryl- and N-alkyl-substituted 4-piperidones, in which the N substituent can easily be varied.A number of intramolecular donor-acceptor systems was synthesized from these piperidones by conversion of the carbonyl functionality.The influence of the N-aryl donor on the electronic absorption and fluorescence spectra was investigated systematically.It was concluded that some systems can be used as efficient fluorescent probes with a high sensitivity for solvent polarity.