116253-76-0

Basic information

• Product Name: Quinoline, 8-(4-nitrophenoxy)-
• CAS NO: 116253-76-0
• Molecular Formula: C15H10N2O3
• Molecular Weight: 266.256
• Mol File: 116253-76-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Quinoline, 8-(4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 8-(4-nitrophenoxy)-(116253-76-0)
• EPA Substance Registry System: Quinoline, 8-(4-nitrophenoxy)-(116253-76-0)

Safety Data

• Hazardous Substances Data: 116253-76-0(Hazardous Substances Data)

Upstream product

• 148-24-3 8-quinolinol 
• 100-00-5 4-chlorobenzonitrile 
• 17763-80-3 para-nitrophenyl triflate 
• 222713-64-6 8-((tert-butyldimethylsilyl)oxy)quinoline 
• 350-46-9 4-Fluoronitrobenzene 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 116253-63-5 4-(quinolin-8-yloxy)aniline 

Relevant articles and documents

Base-mediated N- And O-arylations of NH-containing heterocycles, heterocyclic amines and phenols

Nucleophilic substitution reactions of N-heterocycles such as imidazole, benzimidazole, indole and pyrazole as well as NH2 or OH containing heterocycles, with electron-deficient aryl halides in the presence of t-BuOK or K2CO3as base and DMSO as solvent are reported. A series of N-aryl azoles, unsymmetric diaryl ethers and diaryl amines were obtained in good yields.

Synthesis of diaryl ethers, diaryl sulfides, heteroaryl ethers and heteroaryl sulfides under microwave dielectric heating

This paper describes the synthesis of diaryl ethers and sulfides by utilizing microwave heating methodology. The methodology is shown to be rapid and efficient for the coupling of phenols or thiophenol with electron-deficient aryl halides through a SNAr reaction. The scope of the protocol can be expanded to six-membered heterocycles bearing a hydroxyl group as well as to the reaction of 2-pyrimidinethiol with mildly activated aryl halides, providing heteroaryl ethers and sulfides, respectively. The advantages of the present method include the wide substrate scope, the obviation of metal catalysts, ease of product isolation, and high purity of products. Georg Thieme Verlag Stuttgart.

A general and efficient protocol for the synthesis of biaryl ethers from aryl silyl ethers using Cs2CO3

A general and efficient one-step procedure has been developed for the synthesis of biaryl ethers via direct coupling of electron-deficient arylhalides or aryl triflates to aryl t-butyldimethylsilyl (TBS) ethers using Cs 2CO3. The protocol was also applied to electron-rich arylhalides by addition of a catalytic amount of copper(I) iodide. The reaction is rapid and provides good to excellent yields.