1162680-35-4

Basic information

• Product Name: N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide
• Synonyms: N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide
• CAS NO: 1162680-35-4
• Molecular Weight: 459.888
• Mol File: 1162680-35-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide(1162680-35-4)
• EPA Substance Registry System: N-(6-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridin-2-yl)acetamide(1162680-35-4)

Safety Data

• Hazardous Substances Data: 1162680-35-4(Hazardous Substances Data)

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 887309-87-7 N-(5-bromo-2-chloro-pyridine-3-yl)-4-fluorobenzenesulfonamide 
• 588729-99-1 3-amino-5-bromo-2-chloropyridine 
• 1112983-31-9 N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide 
• 1162680-84-3 N-(6-bromoimidazo[1,2-a]pyridin-2-yl)acetamide 

Relevant articles and documents

Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: Investigations of various 6,5-heterocycles to improve metabolic stability

N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d] thiazol-2-yl)acetamide (1) is a potent and efficacious inhibitor of PI3Kα and mTOR in vitro and in vivo. However, in hepatocyte and in vivo metabolism studies, 1 was found to undergo deacet