116355-65-8

Upstream product

• 96-35-5 glycolic acid methyl ester 
• 96-34-4 methyl chloroacetate 
• 446-35-5 2,4-Difluoronitrobenzene 
• 446-36-6 5-fluoro-2-nitrophenol 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 103361-99-5 7-fluoro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of prodrugs for nitroreductase based 4-β-amino-4′-Demethylepipodophyllotoxin as potential anticancer agents

A series of prodrugs for nitroreductase (NTR) based 4-β-amino-4′- Demethylepipodophyllotoxin as potential anticancer agents were synthesized, and their antiproliferative activities in vitro showed compounds 2b (IC50 = 0.77, 0.83 and 1.19 μM) an

Synthesis method of 2-(5-fluoro-2-nitrophenoxy)acetate compounds

The invention relates to the field of pesticide chemical industry, and concretely relates to a synthesis method of 2-(5-fluoro-2-nitrophenoxy)acetate compounds. The method is characterized in that a compound shown as a formula (I) and a compound shown as a formula (II) react under the action of a catalyst to obtain the target products; the catalyst is at least one of sodium iodide and potassium iodide; and in the formulas, R1 is sodium or potassium, and R2 is a C1-C6 alkyl group or a benzyl group. According to the synthesis process, the byproduct potassium chloride generated after the reaction can be effectively separated through simple filtration, so that resource utilization of the byproduct potassium chloride is realized. In addition, the solvent can be recycled by means of evaporating and removing the solvent, so resource waste is greatly reduced, cost is saved, and the environment is protected.

Method for synthetizing 2-(5-fluorine-2-nitryl-phenoxyl) methyl acetate

The invention discloses a method for synthetizing 2-(5-fluorine-2-nitryl-phenoxyl) methyl acetate. According to the method, 2,4-difluoronitrobenzene is used as raw materials; the 2-(5-fluorine-2-nitryl-phenoxyl) methyl acetate (a flumioxazin intermediate) is obtained through hydroxy substitution and etherification reaction. The synthesis method provided by the invention has the advantages that the 2,4-difluoronitrobenzene is used as raw materials; the price is low; the obtaining is easy, so that the production cost is reduced to a certain degree; the intermediate 1 directly reacts with methyl chloroacetate; the operation is simple; the raw materials can be repeatedly used, so that the production cost is reduced; through etherification reaction, byproducts of hydrochloric acid are recovered; no byproducts of sylvite are generated; environment-friendly and green effects are achieved; the aftertreatment operation is simple and convenient; in addition, the raw materials are cheap and can be easily obtained; the reaction condition are mild; the operation is simple and convenient; the popularization to scale production is favorably realized.

2 - (5 - fluoro - 2, 4 - II nitrobenzene oxygen) acetate synthesis method

The invention belongs to the field of chemical sythensis, and particularly relates to a synthetic method of 2-(5-fluoro-2,4-nitrophenoxy)acetate. The invention aims to solve the technical problem that the separation and purification of a product is difficult, and the production cost is high. For solving the technical problem, the synthetic method of 2-(5-fluoro-2,4-nitrophenoxy)acetate is provided. The synthetic method comprises the following steps: a, reacting 2,4-difluoronitrobenzene with glycolate under the action of an acid-binding agent so as to obtain a mixture of 2-(5-fluoro-2-nitrophenoxy)acetate and 2-(3-fluoro-4-nitrophenoxy)acetate; b, reacting the mixture obtained in the step a with nitric acid to obtain 2-(5-fluoro-2,4-dinitrophenoxy)acetate. According to the synthetic method, raw materials are cheap and easily available, reaction selectivity is good, side reaction is less, product yield in high, reaction condition is mild and easy to control, and process is simple to operate and easy to industrialize.

Herbicidal glutarimides

This invention relates to glutarimide compounds exhibiting herbicidal activity having the structure STR1 wherein A is carbonyl, thiocarbonyl or methylene, A1 is carbonyl or methylene, Q is O or (CH2)n where n is 0 or 1, D is CH or N and R, R1, R2, T, X, Y and Z are as defined within, compositions containing these compounds and methods of using these compounds as herbicides and algicides.

Herbicidal glutaramic acids and derivatives

This invention relates to glutaramic acids and derivatives exhibiting herbicidal activity having the structure STR1 wherein A is a carboxylic acid or a derivative thereof, D is CH or N, and R, R1, R2, T, X, Y, and Z are as defined within, compositions containing these compounds and methods of controlling weeds with these compounds.