116382-72-0

Upstream product

• 16251-45-9 (4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one 
• 79-03-8 propionyl chloride 
• 802294-64-0 propionic acid 
• 492-41-1 (1R,2S)-norephedrine 
• 4122-52-5 1-(1H-imidazol-1-yl)propan-1-one 

Downstream Products

• 122647-45-4 C₄₃H₇₁NO₁₀Si 
• 185670-10-4 (3-(2R,3S,4R)4R,5R)-3-(3-hydroxy-1-oxo-2,4,8-trimethyl-7-nonenyl)-4-methyl-5-phenyl-2-oxazolidinone 
• 157318-10-0 (4S,5R)-3-((2S,3S)-4-Benzyloxy-3-hydroxy-2-methyl-butyryl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 165036-40-8 (4S,5R)-4-methyl-3-<(2R,3R)-2-methyl-3-phenyl-3-(tosylamino)propionyl>-5-phenyloxazolidin-2-one 
• 164913-51-3 (4S,5R)-4-methyl-3-<(2R,3S)-2-methyl-3-phenyl-3-(tosylamino)propionyl>-5-phenyloxazolidin-2-one 
• 179944-89-9 (4S,5R)-3-((2S,3R,4R)-5-Benzyloxy-3-hydroxy-2,4-dimethyl-pentanoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 178113-53-6 (4S,5R)-3-((2S,3R)-3-hydroxy-2-methyl-1-oxodecanyl)-4-methyl-5-phenyl-2-oxazolidinone 
• 187328-75-2 (4S,5R)-3-((E)-(2R,3S)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 199612-89-0 (4S,5R)-3-((R)-4-Bromo-2-methyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 209671-24-9 (4S,5R)-3-((2'R,3'R)-3'-hydroxy-2'-methylpentanoyl)-4-methyl-5-phenyl-2-oxazolidinone 
• 223564-49-6 (2'R,4S,5R)-(-)-3-(2'-Methyl-4'-ethyl-1'-oxopent-4'-enyl)-4-methyl-5-phenyloxazolidin-2-one 
• 329796-41-0 (4S,5R)-3-((2S,3R)-3-Hydroxy-2-methyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 312962-11-1 (4S,5R)-3-((2R)-2,5-dimethyl-hex-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 483305-59-5 (4S,5R)-3-[(2S,3R)-3-Hydroxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanoyl]-4-methyl-5-phenyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Chemoselective N-acylation of indoles and oxazolidinones with carbonylazoles

Unique reactivity: In the presence of more reactive amine and alcohol functional groups and of carboxylic acids, the chemoselective N-acylation of indoles (see scheme) and oxazolidinones is achieved by taking advantage of the unique reactivity of carbonylazole acylating agents with catalytic amounts of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). Copyright

Total Syntheses of Amphidinolide T1, T3, T4, and T5

A concise, flexible, and high yielding entry into the family of amphidinolide T macrolides, a series of cytotoxic natural products of marine origin, has been developed. All individual members, except amphidinolide T3 (3), derive from compound 39 as a comm

Stereoselective synthesis of pamamycin-607

A macrodiolide antibiotic pamamycin-607 was synthesized by joining two hydroxy acid components. Three cis-2, 5-disubstituted tetrahydrofuran rings in the molecule were stereoselectively prepared by radical cyclization reactions of β-alkoxyvinyl ketone intermediates and a β-alkoxymethacrylate substrate. The key step of the synthesis is characterized by the predominant threo product formation in the radical cyclization reaction of a β-alkoxymethacrylate intermediate.

A synthetic library of cell-permeable molecules

Small molecules that induce or stabilize the association of macromolecules have proven to be useful effectors of a wide variety of biological processes. To date, all examples of such chemical inducers of dimerization have involved known ligands to well-ch

Palladium-catalyzed intramolecular allylic alkylation reaction in marine natural product synthesis: Enantioselective synthesis of (+)-methyl pederate, a key intermediate in syntheses of mycalamides

A novel preparation of (+)-methyl pederate (4), a key intermediate in syntheses of mycalamides (1), marine natural products from a New Zeland sponge of the genus Mycale, is described. The key step involves palladium- catalyzed intramolecular allylic alkylation of the carbonate 21, derived from (+)-(4R,5R,E)-5-(tert-butyldimethylsiloxy)-4-methyl-2-hexenol (13), yielding lactones 5 in 87% yield. Demethoxycarbonylation of the cyclization products 5 and further functional group transformations led to (+)-methyl pederate (4).

Enantioselective synthesis of 2-substituted 4-aminobutanoic acid (GABA) analogues via cyanomethylation of chiral enolates

Cyanomethylation by bromoacetonitrile of sodium or lithium enolates derived from (4S,5R)-3-acyl-4-methyl-5-phenyl-1,3-oxazolidin-2-ones usually shows good stereoselecrivity; although the reaction of 3-(3-carboxypropanoyl)oxazolidinone 5d is exceptionally