1164474-54-7

Basic information

• Product Name: 5-[(E)-2-phenylvinyl]-2-(4-tolyl)-1,3,4-oxadiazole
• Synonyms: 5-[(E)-2-phenylvinyl]-2-(4-tolyl)-1,3,4-oxadiazole
• CAS NO: 1164474-54-7
• Molecular Weight: 262.311
• Mol File: 1164474-54-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-[(E)-2-phenylvinyl]-2-(4-tolyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(E)-2-phenylvinyl]-2-(4-tolyl)-1,3,4-oxadiazole(1164474-54-7)
• EPA Substance Registry System: 5-[(E)-2-phenylvinyl]-2-(4-tolyl)-1,3,4-oxadiazole(1164474-54-7)

Safety Data

• Hazardous Substances Data: 1164474-54-7(Hazardous Substances Data)

Upstream product

• 827-58-7 2-p-tolyl-1,3,4-oxadiazole 
• 42599-24-6 E-styryl iodide 
• 140-10-3 (E)-3-phenylacrylic acid 
• 3619-22-5 p-toluic hydrazide 
• 101349-79-5 2-phenylvinyl iodide 
• 100-42-5 styrene 

Relevant articles and documents

Palladium-Catalyzed Cross-Coupling of 1,3,4-Oxadiazoles and Styrenes: An Efficient Method to Synthesize 2-Alkenyl-1,3,4- Oxadiazoles §

2-Alkenyl-1,3,4-oxadiazole derivatives have been prepared by cross-coupling of 1,3,4-oxadiazoles with styrenes by using palladium(II) trifluoroacetate [Pd(TFA) 2 ] as a catalyst, 1,10-phenanthroline as a ligand, silver trifluoroacetate as an oxidant, and toluene as a solvent. The products were formed in high yields and no byproducts were detected.

Copper-catalyzed direct cross coupling of 1,3,4-oxadiazoles with trans-β-halostyrenes: Synthesis of 2-E-vinyl 1,3,4-oxadiazoles

The first direct C-H alkenylation of 1,3,4-oxadiazoles with trans-β-halo olefinic system has been carried out using a combination of CuI/DMEDA as a catalyst. A wide range of 2-E-vinyl-substituted oxadiazoles were obtained in high yields (85-93%).