116480-53-6

Basic information

• Product Name: 5-BROMO-3-(1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE
• Synonyms: 5-BROMO-3-(1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE;5-Bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole;5-bromo-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-1H-indole
• CAS NO: 116480-53-6
• Molecular Formula: C₁₄H₁₅BrN₂
• Molecular Weight: 291.1863
• Mol File: 116480-53-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 266-268℃
• Appearance: /
• CAS DataBase Reference: 5-BROMO-3-(1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-(1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE(116480-53-6)
• EPA Substance Registry System: 5-BROMO-3-(1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE(116480-53-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 116480-53-6(Hazardous Substances Data)

Upstream product

• 10075-50-0 5-bromo-1H-indole 
• 931-20-4 1-methylpiperidin-2-one 
• 123-75-1 pyrrolidine 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 253439-59-7 5-(4-(4-Fluorobenzamido)phenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 253439-70-2 5-(4-methoxyphenyl)-3-(1-methylpiperidin-4-yl)-1-(triisopropylsilyl)-indole 
• 253439-68-8 5-phenyl-3-(1-methylpiperidin-4-yl)-1-(triisopropylsilyl)-indole 
• 253439-61-1 5-(4-Acetamidophenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 253439-62-2 5-(4-Acetylphenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 253439-64-4 5-(4-Aminophenyl)-3-(1-Methylpiperidin-4-yl)-1H-Indole 
• 121206-76-6 5-Bromo-3-(1-methyl-4-piperidinyl)-1H-indole 

Relevant articles and documents

An improved process for the synthesis of 5-bromo-3-(1-methylpiperidin-4-yl) -1 H-indole: A key intermediate in the synthesis of naratriptan hydrochloride

An improved process has been developed for the synthesis of 5-bromo-3-(1-methylpiperidin-4-yl)-1H-indole, a key intermediate of naratriptan hydrochloride, which is used as a drug for migraine. A novel one-pot synthetic procedure using triethyl silane was developed for scale-up.

Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins

The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compounds of the present invention can also be used in the treatment of ocular diseases associated with pathological abnormalities/changes in the tissues of the visual system. The present invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the preparation of medicaments for treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins. A method of treating or preventing diseases or conditions associated with amyloid and/or amyloid-like proteins is also disclosed.

PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY

Described herein are indole compounds with affinity for the 5-HT6 receptor, which have general formula (I) wherein, R is selected from the group consisting of H and C1-4alkyl; R is selected from the group consisting of H, C1-4alkyl and benzyl; -----