116502-80-8Relevant articles and documents
Total synthesis of calicheamicinone: New arrangements for actuation of the reductive cycloaromatization of aglycon congeners
Haseltine, John N.,Cabal, Maria Paz,Mantlo, Nathan B.,Iwasawa, Nobuharu,Yamashita, Dennis S.,Coleman, Robert S.,Danishefsky, Samuel J.,Schulte, Gayle K.
, p. 3850 - 3866 (2007/10/02)
The total synthesis of dl-calicheamicinone (1) has been accomplished. The key elements of the synthesis were (i) an application of the Becker-Adler reaction to reach compound 91, (ii) an application of the concept of in situ protection to deliver lithiate