116510-05-5Relevant articles and documents
BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
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, (2011/07/29)
Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
PtCl2-catalyzed cyclization of o-diethynylbenzene derivatives triggered by intramolecular nucleophilic attack
Miki, Koji,Kuge, Hiroyuki,Umeda, Rui,Sonoda, Motohiro,Tobe, Yoshito
experimental part, p. 1077 - 1087 (2011/04/25)
(Chemical Equation Presented) PtCl2-catalyzed cyclization of o-diethynylbenzene derivatives bearing a hydroxyethyl group yielded naphthofuran derivatives by initial intramolecular cyclization of the hydroxy group to an activated ethynyl group followed by attack of the second ethynyl group to a vinylplatinum intermediate. When the ethynyl terminal is substituted by a hydroxypropyl group, not only homologous naphthodihydropyran but also indenylidenete-trahydrofuran derivatives were formed. Copyright Taylor & Francis Group, LLC.
BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
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Page/Page column 35-36, (2008/06/13)
Provided are bis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or tre
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation
Zheng, Guangrong,Zhang, Zhenfa,Pivavarchyk, Marharyta,Deaciuc, Agripina G.,Dwoskin, Linda P.,Crooks, Peter A.
, p. 6734 - 6738 (2008/03/14)
A series of conformationally restricted bis-azaaromatic quaternary ammonium salts (3 and 4) have been designed and synthesized in order to investigate the possible binding conformations of N,N′-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB; 2), a
High temperature radical cyclization anomalies in the tandem enediyne-bis-radical cyclization
Grissom, Janet Wisniewski,Calkins, Trevor L.,Huang, Dahai,McMillen, Heidi
, p. 4635 - 4650 (2007/10/02)
Previous reports have shown that the thermolysis of aromatic enediynes containing radical accepting tethers will undergo tandem enediyne-radical cyclizations. Herein will be reported several examples of the tandem enediyne-bis-radical cyclization where no
Synthetic studies of the tandem enediyne-mono- and bis-radical cyclizations
Grissom, Janet Wisniewski,Calkins, Trevor L.,Egan, Miles
, p. 11744 - 11752 (2007/10/02)
The readily synthesized enediynes 12a-j possessing a tethered olefin radical acceptor can participate in a tandem enediyne-radical cyclization to yield dihydrobenzindene derivatives 14a-j. In the present study, the scope of this reaction was expanded to i
THE SYNTHESIS OF 11-13 MEMBERED DIACETYLENIC AND 18-MEMBERED TETRAACETYLENIC RING SYSTEMS
Just, George,Singh, Rina
, p. 5981 - 5984 (2007/10/02)
The sysnthesis of title compounds is described, starting from o-dibromobenzene.The palladium catalysed coupling of the latter with acetylenes occurred in a step-wise fashion, when no cocatalyst (CuI) was used.