116532-63-9

Basic information

• Product Name: Aniline, N-methyl-2,3-methylenedioxy- (6CI)
• Synonyms: Aniline, N-methyl-2,3-methylenedioxy- (6CI);N-methyl-1,3-benzodioxol-4-amine
• CAS NO: 116532-63-9
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16256
• Mol File: 116532-63-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 261.3±29.0 °C(Predicted)
• Appearance: /
• Density: 1.258±0.06 g/cm3(Predicted)
• PKA: 4.54±0.20(Predicted)
• CAS DataBase Reference: Aniline, N-methyl-2,3-methylenedioxy- (6CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Aniline, N-methyl-2,3-methylenedioxy- (6CI)(116532-63-9)
• EPA Substance Registry System: Aniline, N-methyl-2,3-methylenedioxy- (6CI)(116532-63-9)

Safety Data

• Hazardous Substances Data: 116532-63-9(Hazardous Substances Data)

Upstream product

• 1137558-01-0 benzyl benzo[d][1,3]dioxol-4-yl(methyl)carbamate 
• 274-09-9 Methylenedioxybenzene 
• 25370-97-2 O-(p-toluenesulfonyl)-N-methylhydroxylamine 
• 72744-45-7 4-nitro-(1,3-benzodioxolyl) 
• 6665-98-1 3-nitrobenzene-1,2-diol 
• 103441-84-5 4-methylamino-benzo[1,3]dioxole-5-carboxylic acid 
• 1668-84-4 benzo[d][1,3]dioxol-4-amine 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

A Metal-Free Direct Arene C?H Amination

The synthesis of aryl amines via the formation of a C?N bond is an essential tool for the preparation of functional materials, active pharmaceutical ingredients and bioactive products. Usually, this chemical connection is only possible by transition metal-catalyzed reactions, photochemistry or electrochemistry. Here, we report a metal-free arene C?H amination using hydroxylamine derivatives under benign conditions. A charge transfer interaction between the aminating reagents TsONHR and the arene substrates enables the chemoselective amination of the arene, even in the presence of various functional groups. Oxygen was crucial for an effective conversion and its accelerating role for the electron transfer step was proven experimentally. In addition, this was rationalized by a theoretical study which indicated the involvement of a dioxygen-bridged complex with a “Sandwich-like” arrangement of the aromatic starting materials and the aminating agents at the dioxygen molecule. (Figure presented.).

Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities

An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In addition, X-ray crystallography studies of QR2 in complex with compound 1 and one of its more potent analogues has provided insight into the mechanism of action of this new series of QR2 inhibitors. The initial biological investigations suggest that compound 1 and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents.