72744-45-7

Basic information

• Product Name: 4-Nitrobenzo[d][1,3]dioxole
• Synonyms: 4-Nitrobenzo[d][1,3]dioxole
• CAS NO: 72744-45-7
• Molecular Weight: 167.121
• Mol File: 72744-45-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Nitrobenzo[d][1,3]dioxole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrobenzo[d][1,3]dioxole(72744-45-7)
• EPA Substance Registry System: 4-Nitrobenzo[d][1,3]dioxole(72744-45-7)

Safety Data

• Hazardous Substances Data: 72744-45-7(Hazardous Substances Data)

Upstream product

• 6665-98-1 3-nitrobenzene-1,2-diol 
• 75-11-6 diiodomethane 
• 274-09-9 Methylenedioxybenzene 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 1668-84-4 benzo[d][1,3]dioxol-4-amine 
• 98224-27-2 1-(1,3-benzodioxol-4-yl)piperazine 
• 116532-63-9 N-methylbenzo[d][1,3]dioxol-4-amine 

Relevant articles and documents

2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS

The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

Influence of the Heterocyclic Side Ring on Orientation During Nitrations of 1,2-Alkylenedioxy-annelated Benzenes and Their Mononitro Derivatives

Nitration of 1,2-alkylenedioxybenzenes 1 furnished the respective nitro derivatives 3 and 4 in the relative ratios: 4a:3a/100:trace, 4b:3b/98:2.4, 4c:3c/86:14, 4e:3e/91:9, 4f:3f/99:1.3.Nitration of 4 gave 5a:6a:8a/0:0:100, 5b:6b:8b/7.7:3.2:89, 5c:6c:8c/23:12:65, 5d:6d:8d/14:74:12, 5e:6e:8e/27:18:55 and 5f:6f:8f/23:7.0:70.Nitration of the isomeric 3 afforded the dinitroproducts 5, 6 and 7 in the following relative ratios: 5a:6a:7a/92:8:0, 5b:6b:7b/80:20:0, 5c:6c:7c/69:20:11, 5d:6d:7d/45:19:36, 5e:6e:7e/37:57:5.9 and 5f:6f:7f/64:36:0.Nitration of 3-nitro-1,2-dimethoxybenzene (9) furnished: 10:11/63:37.Orientation as a function of the h eterocyclic ring-size is discussed.