116573-93-4

Basic information

• Product Name: 2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl]5-isopropyl ester
• Synonyms: 2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl]5-isopropyl ester;2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl]5-isopropyl ester
• CAS NO: 116573-93-4
• Molecular Weight: 0
• Mol File: 116573-93-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl]5-isopropyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl]5-isopropyl ester(116573-93-4)
• EPA Substance Registry System: 2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)azetidin-3-yl]5-isopropyl ester(116573-93-4)

Safety Data

• Hazardous Substances Data: 116573-93-4(Hazardous Substances Data)

Upstream product

• 123524-52-7 azelnidipine 
• 542-08-5 isopropyl acetoacetate 
• 39562-25-9 3-oxo-2-(3-nitrophenylmethylene)butanoic acid isopropyl ester 
• 170749-59-4 1-benzhydrylazetidin-3-yl 3-amino-3-iminopropanoate acetate 
• 5468-46-2 2-cyano-3-(3'-nitro-1'-phenyl)acrylic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 14205-46-0 isopropyl 3-aminocrotonate 

Downstream Products

• 722455-08-5 (-)-Azelnidipine 
• 722455-09-6 (+)-Azelnidipine 
• 918659-10-6 3-(1-benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate 

Relevant articles and documents

Azelnidipine preparation method (by machine translation)

The invention relates to a blood pressure lowering medicine azhediping preparation method, which belongs to the field of medicine. The method of the traditional synthetic route trunk compound 4 of the improved synthetic conditions, of the original anhydrous reaction conditions is changed into the water under the conditions of the reaction, not only is easy to operate, but also to reduce the requirement of anhydrous reaction solvent, thus very suitable for industrial production. (by machine translation)

OPTICALLY ACTIVE DIHYDROPYRIDINE DERIVATIVE

The optically active dihydropyridine derivative is (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) ester 5-isopropyl ester or a pharmacologically acceptable salt thereof.

Dihydropyridine derivatives, their preparation and their use

2-(Amino or methyl)-6-(methyl or amino)-4-(substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid esters have a specific class of heterocyclic groups as thealcohol moiety. These compounds have a variety of valuable activities, including antihypertensive and Ca++ -blocking activities, leading to their use for the treatment of circulatory and coronary disorders. They may be prepared by condensation of appropriate substituted benzylideneacetoacetic acid esters with appropriate amidinoacetic acid esters.