1165944-75-1

Upstream product

• 75-52-5 nitromethane 
• 4173-44-8 6-phenylhexa-3,5-dien-2-one 
• 947740-50-3 1-Nitro-4-phenyl-butadien 
• 67-64-1 acetone 
• 4701-10-4 ((1E,3E)-4-nitrobuta-1,3-dien-1-yl)benzene 
• 14371-10-9 (E)-3-phenylpropenal 

Relevant academic research and scientific papers

Highly Enantioselective Michael Addition of Aromatic Ketones to Nitrodienes and the Application to the Synthesis of Chiral γ-Aminobutyric Acid

A highly enantioselective Michael addition of aromatic ketones to α,β,γ,δ-unsaturated nitro compounds is described. In the presence of a chiral primary amine-thiourea based on dehydroabietic amine, γ-nitro ketones were obtained in excellent enantioselecti

Enantioselective organocatalytic michael addition of aliphatic ketones to nitrodienes

A highly enantioselective Michael addition of aliphatic ketones to nitrodienes has been achieved that is catalyzed by readily available chiral thioureas derived from (1R,2R)-diphenylethane-1,2-diamine. Treatment of ketones with nitrodienes in the presence

Organocatalytic "difficult" michael reaction of ketones with nitrodienes utilizing a primary amine-thiourea based on Di-tert-butyl aspartate

The primary amine-thiourea based on di-tert-butyl (S)-aspartate and (1R,2R)-1,2-diphenylethylene-1,2-diamine has been successfully employed in the "difficult" Michael reaction between aromatic ketones or acetone with nitrodienes. The high stability and re

A recyclable organocatalyst for asymmetric Michael addition of acetone to nitroolefins

Based on different chiral diamine skeletons, a series of bifunctional primary amine-thiophosphoramides were synthesized and screened as the catalysts for the asymmetric Michael addition of acetone to both aromatic and aliphatic nitroolefins. Under the cat

Highly enantioselective michael addition of acetone to nitro olefins catalyzed by chiral bifunctional primary amine-thiophosphoramide catalyst

A series of bifunctional primary amine-thiophosphoramides were synthesized, which proven to be effective organocatalysts for the asymmetric Michael reaction of acetone to both aryl and alkyl nitro olefins in the presence of phenol as a protic additive. The corresponding adducts were obtained in excellent chemical yields (up to >99%) with excellent enantioselectivities (up to 97% ee). A novel chiral phosphoramide functions well as an efficient bifunctional organocatalyst for the asymmetric Michael addition of acetone, one of the most challenge substrate in Michael addition, to nitro olefinsto afford the corresponding syntheticvaluable γ-nitro ketones in good to excellent yield with high levels of enantioselectivities (up to 97% ee, respectively).

Simple Cyclohexanediamine-Derived Primary Amine Thiourea Catalyzed Highly Enantioselective Conjugate Addition of Nitroalkanes to Enones

A highly enantioselective conjugate addition of nitroalkanes to enones has been developed. The process Is efficiently catalyzed by a simple chiral cyclohexanediamine-derived primary amine thiourea with a broad substrate scope.