116597-12-7

Upstream product

• 958-09-8 2'-deoxy-D-adenosine 
• 116597-14-9 N⁶-benzoyl-9-(3-O-benzoyl-2-deoxy-β-D-threo-pentofuranosyl)adenine 
• 104769-16-6 N⁶-benzoyl-5'-O-benzoyl-2'-deoxyadenosine 

Downstream Products

• 66323-44-2 9-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)adenine 
• 869354-89-2 3'-azido-N₆-benzoyl-2',3'-dideoxyadenosine 

Relevant academic research and scientific papers

Anchimeric Assistance of a 5'-O-Carbonyl Function for Inversion of Configuration at the 3'-Carbon Atom of 2'-Deoxyadenosine. Synthesis of 3'-Azido-2',3'-dideoxyadenosine and 3'-Azido-2',3'-dideoxyinosine

3'-Azido-2',3'-dideoxyadenosine was synthesized in two steps from N6,5'-O-dibenzoyl-2'-deoxyadenosine in 65percent yield.The configuration at the 3' position was inverted by reaction of N6,5'-O-dibenzoyl-2'-deoxyadenosine with trifli

Study on disulfur-backboned nucleic acid: Part 1, efficient synthesis of 3′,5′-dithio-2′-deoxyadenosine

An efficient procedure is established to synthesize 3′,5′- dithio-2′-deoxyadenosine starting from 2′-deoxyadenosine in five steps in 33% overall yield. In this procedure, the key intermediate 9 was synthesized by twice SN2 reactions with twice

3'-(2')-amino or thiol-modified, fluorescent dye-coupled oligonucleotides and a process for the preparation and the use thereof

The OH group located in the 3' and/or 2' position of a nucleoside, nucleotide or oligonucleotide is derivatized to an amino or thiol group and subsequently a fluorescent dye is coupled thereto. The resulting 3'- and/or 2'-amino- and thiol-modified nucleosides, nucleotides and oligonucleotides can then be used for the synthesis of complementary strands in the presence of a template strand or of oligonucleotides and for the detection of genetic material. They have the advantage that the fluorescent label need no longer be attached to the 5' end of the oligonucleotide or to the nucleobase, and thus need not be introduced during the chemical synthesis as in labeling techniques hitherto known, while the known and conventional methods have the disadvantage that only a few polymerases can be employed for the synthesis, the acceptance of the triphosphates by the polymerases diminishes and, moreover, a large substrate excess is necessary.

Synthesis and application of 3′-amino-dye-terminators for dna sequencing

The synthesis of 3′-aminomodified nucleoside 5′-triphosphates and their coupling with oligoaminoacid-linked dyes is described. Application for DNA dye-terminator sequencing was investigated. Copyright 1997 by Marcel Dekker, Inc.