116597-85-4

Upstream product

• 100-39-0 benzyl bromide 
• 1531-12-0 norlevorphanol 
• 102558-09-8 4-((S)-2-benzyl-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol 
• 100-44-7 benzyl chloride 
• 74570-02-8 4-((S)-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol 
• 102558-09-8 (+/-)-4-(2-benzyl-1,2,3,4,5,6,7,8-octahydro-[1]isoquinolylmethyl)-phenol 
• 125-71-3 dextromethorphan 
• 1087-69-0 (+)-3-Methoxymorphinan hydrochloride 
• 58434-39-2 C₁₉H₂₅NO₃ 
• 77-07-6 Levorphanol 

Downstream Products

• 1079043-55-2 [2H]-Dextromethorphan 3,17-d6 

Relevant academic research and scientific papers

INDUSTRIAL PROCESS OF MONO-ALKYLATING A PIPERIDINE NITROGEN IN PIPERIDINE DERIVATIVES WITH DEUTERATED-ALKYL

The present invention relates to a method of mono-alkylating a piperidine nitrogen in a piperidine derivative with a deuterated lower-alkyl, which comprises protecting the piperidine nitrogen with an aralkyl protective group, lower-alkylating the piperidine nitrogen with a deuterated-lower-alkylating agent under neutral or basic condition, and then deprotecting the aralkyl protective group.

Mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: Synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan

A series of new N-substituted derivatives of morphinan was synthesized and their binding affinity for the three opioid receptors (μ, δ, and κ) was determined. A paradoxical effect of N-propargyl (MCL-117) and N-(3-iodoprop-(2E)-enyl) (MCL-118) substituents on the binding affinities for the μ and κ opioid receptors was observed. All of these novel derivatives showed a preference for the μ and κ versus δ binding.