1167440-59-6

Basic information

• Product Name: N‐benzyl‐5‐methylthiazol‐2‐amine
• Synonyms: N‐benzyl‐5‐methylthiazol‐2‐amine
• CAS NO: 1167440-59-6
• Molecular Weight: 204.296
• Mol File: 1167440-59-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N‐benzyl‐5‐methylthiazol‐2‐amine(CAS DataBase Reference)
• NIST Chemistry Reference: N‐benzyl‐5‐methylthiazol‐2‐amine(1167440-59-6)
• EPA Substance Registry System: N‐benzyl‐5‐methylthiazol‐2‐amine(1167440-59-6)

Safety Data

• Hazardous Substances Data: 1167440-59-6(Hazardous Substances Data)

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 2450-71-7 Propargylamine 
• 7305-71-7 5-methyl-2-thiazol-2-amine 
• 1666-17-7 benzaldehyde p-toluenesulfonylhydrazone 
• 1192837-57-2 C₁₁H₁₀N₂S 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

Microwave-Assisted Domino Reactions of Propargylamines with Isothiocyanates: Selective Synthesis of 2-Aminothiazoles and 2-Amino-4-methylenethiazolines

A simple and versatile microwave-assisted protocol for the synthesis of 2-aminothiazoles has been developed. The domino reaction of propargylamines and isothiocyanates in the presence of catalytic PTSA leads to the selective synthesis of 2-aminothiazoles

Manganese catalyzed reductive amination of aldehydes using hydrogen as a reductant

A one-pot two-step procedure was developed for the alkylation of amines via reductive amination of aldehydes using molecular dihydrogen as a reductant in the presence of a manganese pyridinyl-phosphine complex as a pre-catalyst. After the initial condensation step, the reduction of imines formed in situ is performed under mild conditions (50-100 °C) with 2 mol% of catalyst and 5 mol% of tBuOK under 50 bar of hydrogen. Excellent yields (>90%) were obtained for a large combination of aldehydes and amines (40 examples), including aliphatic aldehydes and amino-alcohols.

Impregnated ruthenium on magnetite as a recyclable catalyst for the N-alkylation of amines, sulfonamides, sulfinamides, and nitroarenes using alcohols as electrophiles by a hydrogen autotransfer process

Various impregnated metallic salts on magnetite have been prepared, including cobalt, nickel, copper, ruthenium, and palladium salts, as well as a bimetallic palladium - copper derivative. Impregnated ruthenium catalyst is a versatile, inexpensive, and simple system for the selective N-monoalkylation of amino derivatives with poor nucleophilic character, such as aromatic and heteroaromatic amines, sulfonamides, sulfinamides, and nitroarenes, using in all cases alcohols as the initial source of the electrophile, through a hydrogen autotransfer process. In the case of sulfinamides, this is the first time that these amino compounds have been alkylated following this strategy, allowing the use of chiral sulfinamides and secondary alcohols to give the alkylated compound with a diastereomeric ratio of 92:8. In these cases, after alkylation, a simple acid deprotection gave the expected primary amines in good yields. The ruthenium catalyst is quite sensitive, and small modifications of the reaction medium can change the final product. The alkylation o amines using potassium hydroxide renders the N-monoalkylated amines, and the same protocol using sodium hydroxide yields the related imines. The catalyst can be easily removed by a simple magnet and can be reused up to ten times, showing the same activity.