116753-60-7Relevant academic research and scientific papers
N-heterocyclic carbene catalysed oxygen-to-carbon carboxyl transfer of indolyl and benzofuranyl carbonates
Thomson, Jennifer E.,Kyle, Andrew F.,Gallagher, Katherine A.,Lenden, Philip,Concellon, Carmen,Morrill, Louis C.,Miller, Andrew J.,Joannesse, Caroline,Slawin, Alexandra M. Z.,Smith, Andrew D.
experimental part, p. 2805 - 2818 (2009/04/04)
The ability of N-heterocyclic carbenes to promote O-to-C carboxyl transfer on a range of indolyl and benzofuranyl carbonates is examined, and the scope and limitations of this process delineated. Georg Thieme Verlag Stuttgart.
SOME NEW ANALOGUES OF VERAPAMIL AND MEPAMIL. SYNTHESIS AND BASIC PHARMACOLOGICAL PROPERTIES
Butora, Gabriel,Blaha, Ludvik,Rajsner, Miroslav,Helfert, Ivan
, p. 1967 - 1981 (2007/10/02)
Some new analogues of verapamil (Ia) and mepamil (Ib), calcium antagonists of arylkylamine type, were synthesized and screened for cardiovascular activities.The basic structure was modified a) on the phenyl ring, attached to the quaternary carbon, b) on the alkyl group, attached to the quaternary carbon and c) on the alkylamino group, attached in position 3 to the n-propyl fragment.Except of 2-(2-chlorophenyl)-2-isopropyl-5-(N-methylhomoveratrylamino)valeronitrile (VIa), all the synthesized compounds exhibited lower hypotensive activity, than the mother compound, verapamil.
