116850-28-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-fluorotoluene is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-chloro-3-fluorotoluene serves as a precursor for the production of certain pesticides and herbicides. Its halogenated nature contributes to the effectiveness of these chemicals in controlling pests and weeds.
Used in Dye Industry:
2-Chloro-3-fluorotoluene is utilized as an intermediate in the manufacture of dyes, particularly those requiring specific color properties or stability. Its presence in the dye molecules can enhance their performance in various applications, such as textiles and plastics.
Used in Chemical Research:
2-CHLORO-3-FLUOROTOLUENE is also employed in chemical research for studying the effects of halogen substitution on the properties and reactivity of aromatic compounds. It can provide valuable insights into the development of new synthetic routes and applications for halogenated aromatics.

InChI:InChI=1/C7H6ClF/c1-5-3-2-4-6(9)7(5)8/h2-4H,1H3

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 352-70-5 m-Fluorotoluene 
• 15068-35-6 2-chloro-3-methylbenzoic acid 

Downstream Products

• 1099597-97-3 2-chloro-3-fluorobenzotrifluoride 
• 64248-59-5 1,2-difluoro-3-(trifluoromethyl)benzene 

Relevant academic research and scientific papers

Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Abundant aromatic carboxylic acids exist in great structural diversity from nature and synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic acids is realized mainly by transition-metal-catalyzed decarboxylative cross couplings. However, the high activation barrier for thermal decarboxylative carbometalation that often requires 140 °C reaction temperature limits both the substrate scope as well as the scope of suitable reactions that can sustain such conditions. Numerous reactions, for example, decarboxylative fluorination that is well developed for aliphatic carboxylic acids, are out of reach for the aromatic counterparts with current reaction chemistry. Here, we report a conceptually different approach through a low-barrier photoinduced ligand to metal charge transfer (LMCT)-enabled radical decarboxylative carbometalation strategy, which generates a putative high-valent arylcopper(III) complex, from which versatile facile reductive eliminations can occur. We demonstrate the suitability of our new approach to address previously unrealized general decarboxylative fluorination of benzoic acids.

Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes

The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene, or 3,4-difluorotoluene.

Continuous production method for industrially preparing 2,3-difluorobenzotrifluoride and 3,4-difluorobenzonitrile

The invention discloses a continuous production method for industrially preparing 2,3-difluorobenzotrifluoride and 3,4-difluorobenzonitrile. The preparation process of the 2,3-difluorobenzotrifluoride comprises the preparation step of an intermediate raw material for benzene sulfonamide and benzenesulfonylurea herbicides, and the preparation process of the 3,4-difluorobenzonitrile comprises the preparation step of a cthalofop-butyl intermediate raw material. The method is suitable for industrial production; and compared with the prior art, the method has the advantages of low cost, high production method and less pollution.