15068-35-6

Basic information

• Product Name: 2-Chloro-3-methylbenzoic acid
• Synonyms: 2-CHLORO-3-METHYLBENZOIC ACID;2-CHLORO-M-TOLUIC ACID;3-methyl-2-chlorobenzoic acid;2-Chloro-3-Methyl;2-CHLORO-3-METHYLBENZOIC ACID 98%;2-Chloro-3-methylben
• CAS NO: 15068-35-6
• Molecular Formula: C₈H₇ClO₂
• Molecular Weight: 170.59
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Organic acids;Acids & Esters;Chlorine Compounds
• Mol File: 15068-35-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 142-144°C
• Boiling Point: 288.7 °C at 760 mmHg
• Flash Point: 128.4 °C
• Appearance: white powder
• Density: 1.31 g/cm³
• Vapor Pressure: 0.00107mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 3.08±0.25(Predicted)
• CAS DataBase Reference: 2-Chloro-3-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-methylbenzoic acid(15068-35-6)
• EPA Substance Registry System: 2-Chloro-3-methylbenzoic acid(15068-35-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36/37/39-39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 15068-35-6(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

InChI:InChI=1/C8H7ClO2/c1-5-3-2-4-6(7(5)9)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 858467-66-0 2-chloro-1-isopropenyl-3-methyl-benzene 
• 4389-45-1 3-methylantranilic acid 
• 576-26-1 2.6-dimethylphenol 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 108-38-3 m-xylene 
• 876-99-3 2,6-dimethylphenyl chloroformic acid ester 
• 95-49-8 2-methylchlorobenzene 
• 53003-18-2 4-chloro-5-methyl-1H-indole-2,3-dione 
• 155184-82-0 2-amino-5-methyl-6-chlorobenzoic acid 

Downstream Products

• 90048-72-9 2-Chloro-5-chlorosulfonyl-3-methyl-benzoic acid 
• 21900-56-1 2-chloro-3-methylbenzoyl chloride 
• 920759-93-9 methyl 2-chloro-3-methylbenzoate 
• 1430424-19-3 C₂₁H₂₀ClN₃O₂ 
• 4389-45-1 3-methylantranilic acid 
• 99-04-7 m-Toluic acid 
• 116850-28-3 2-chloro-1-fluoro-3-methylbenzene 

Relevant articles and documents

Preparation method of 3-methyl-2-aminobenzoic acid

The invention discloses a preparation method of 3-methyl-2-aminobenzoic acid. The preparation method comprises the steps that 2-chloro-m-xylene is added into an acetic acid solvent for stirring, sodium acetate is added as a catalyst, the temperature is raised to 80-100 DEG C by heating, hydrogen peroxide is dropped for a reaction, after the reaction, 3-methyl-2-chlorobenzoic acid is obtained through rectification under vacuum; the 3-methyl-2-chlorobenzoic acid is added into a DMSO solvent, and catalysts of copper chloride and sodium carbonate are added and heated to 120-140 DEG C, and then ammonia is introduced and heated to 150-160 DEG C for a heat preservation of 3-6 hours, and the 3-methyl-2-aminobenzoic acid is obtained. According to the preparation method, a new design idea is provided for the synthesis of the 3-methyl-2-aminobenzoic acid, the preparation method is simple, operation is easy, the cost is low, and the preparation method is environmentally friendly.

AMINO ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS

There is provided compounds of formula I, wherein R 1, R 2, R 3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.

6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II)

Compounds of formula I: where: the dashed line denotes an optional bond; R1is H, halo, alkyl, alkyloxy, amino, alkylamino, dialkylamino, or acylamino; R3and R4are independently H, halo, alkyl, alkyloxy, or hydroxy; R5