116853-79-3

Upstream product

• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 421-53-4 2,2,2-trifluoro-1,1-ethanediol 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 99333-34-3 N-(2,2,2-trifluoroethylidene)-4-methoxyaniline 

Downstream Products

• 139285-25-9 4-hydroxy-1-(p-methoxyphenyl)-5-methyl-3-trifluoromethylpyrazole 
• 188817-13-2 SC-560 
• 1617533-11-5 4-isopropyl-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1,4-dihydropyridazine 
• 630382-44-4 1-(4-methoxyphenyl)-3-(trifluoromethyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one 
• 139285-32-8 4-Methoxy-1-(4-methoxy-phenyl)-5-methyl-3-trifluoromethyl-1H-pyrazole 

Relevant academic research and scientific papers

Polysubstituted 3-trifluoromethylpyrazoles: Regioselective (3 + 2)-cycloaddition of trifluoroacetonitrile imines with enol ethers and functional group transformations

Non-catalysed addition of trifluoroacetonitrile imines to enol ethers provided fully regioselectively (3 + 2)-cycloadducts, which either spontaneously or via Br?nsted acid-induced elimination of ROH molecules led to the formation of 3-trifluoromethylated

Trapping of trifluoroacetonitrile imines with mercaptoacetaldehyde and mercaptocarboxylic acids: An access to fluorinated 1,3,4-thiadiazine derivatives via (3+3)-annulation

The in situ generated highly electrophilic nitrile imines derived from trifluoroacetonitrile are efficiently trapped by monomeric mercaptoacetaldehyde at room temperature in THF solution. The initially formed 1:1 adducts undergo spontaneous cyclization le

Novel trifluoromethylated spiro-1,3,4-thiadiazoles via [3+2]-cycloadditions of 2,3-diphenylcyclopropenethione with selected in situ-generated nitrile imines derived from trifluoroacetonitrile

The in situ-generated N-aryl nitrile imines derived from trifluoroacetonitrile react efficiently with 2,3-diphenylcyclopropenethione to give spirocyclic 1,3,4-thiadiazole derivatives as products of a regio- and chemoselective [3+2]-cycloaddition in good t

Expected and unexpected results in reactions of fluorinated nitrile imines with (cyclo)aliphatic thioketones

A series of (cyclo)aliphatic thioketones have been tested towards trifluoroacetonitrile imines, generated in situ via base-induced dehydrohalogenation of the respective hydrazonoyl bromides. Typically, non-enolisable thioketones yielded exclusively 3-trif

Trifluoromethylated 2,3-dihydro-1,3,4-thiadiazoles via the regioselective [3+2]-cycloadditions of fluorinated nitrile imines with aryl, hetaryl, and ferrocenyl thioketones

A series of hydrazonoyl bromides prepared from readily available N-arylhydrazones of fluoral was used for the in situ generation of fluorinated nitrile imines. These 1,3-dipoles were efficiently trapped with aryl and hetaryl thioketones yielding fluoromet

Tautomeric equilibrium in trifluoroacetaldehyde arylhydrazones

Abstract A series of p-substituted phenylhydrazones of trifluoroacetaldehyde (1) was synthesized and the azo-hydrazo (1-2) tautomeric equilibrium was investigated experimentally using correlation analysis and computationally with DFT methods. Investigation revealed strong impact of the substituent and solvent polarity on the tautomeric ratio (1/2). Calculations also revealed that acidity of the azo tautomers is similar to that of malonate esters.

LINEAR CHAIN SUBSTITUTED MONOCYCLIC AND BICYCLIC DERIVATIVES AS FACTOR XA INHIBITORS

The present application descirbes linear chain subtituted monocyclic and byciclic compounds and derivatives thereof of formula (I): P4-P-M-M4 or pharmaceutically acceptable salts from thereof, P-M are rings substituted by a linear group. Compounds of the present invention are useful as inhibitors of trypsin like serine proteases, specifically factor Xa.