Cas 116860-08-3,1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone

116860-08-3

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Basic information

Product Name: 1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone
Synonyms: 1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone
CAS NO:116860-08-3
Molecular Formula:
Molecular Weight: 333.217
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone(CAS DataBase Reference)
NIST Chemistry Reference: 1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone(116860-08-3)
EPA Substance Registry System: 1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone(116860-08-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 116860-08-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 116860-08-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,8,6 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 116860-08:
(8*1)+(7*1)+(6*6)+(5*8)+(4*6)+(3*0)+(2*0)+(1*8)=123
123 % 10 = 3
So 116860-08-3 is a valid CAS Registry Number.

116860-08-3Upstream product

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116860-08-3Relevant academic research and scientific papers

Solvent-free synthesis of some1-acetyl pyrazoles

Thirunarayanan, Ganesamoorthy,Sekar, Krishnamoorthy Guna

, p. 599 - 605 (2013/11/06)

Some N-acetyl pyrazoles including 1-(3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-yl) ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones like substituted styryl 3,4-dichlorophenyl

Synthesis and biological evaluation of pyrazole derivatives containing thiourea skeleton as anticancer agents

Lv, Peng-Cheng,Li, Huan-Qiu,Sun, Juan,Zhou, Yang,Zhu, Hai-Liang

experimental part, p. 4606 - 4614 (2010/08/05)

Two series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(3,4-dimethylphenyl)-5-(4-methoxyphenyl)-4,5- dihydro-1H-pyrazole-1-carbothioamide (C5) displayed the most potent EGFR inhibitory activity with IC50 of 0.07 μM, which was comparable to the positive control erlotinib. Docking simulation was performed to position compound C5 into the EGFR active site to determine the probable binding model. Antiproliferative assay results indicating that some of the pyrazole derivatives own high antiproliferative activity against MCF-7. Compound C5 showed significant antiproliferative activity against MCF-7 with IC50 of 0.08 μM. Therefore, compound C5 with potent inhibitory activity in tumor growth inhibition would be a potential anticancer agent.

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