59826-47-0

Usage

Uses

Used in Pharmaceutical Applications:
Curcumin is utilized as a therapeutic agent for its anti-inflammatory and antioxidant properties, targeting a range of conditions such as arthritis, diabetes, Alzheimer's disease, and cardiovascular diseases. Its ability to modulate molecular targets and signaling pathways involved in these conditions makes it a valuable compound for the development of new treatments.
Used in Anticancer Applications:
Curcumin is employed as an anticancer agent, demonstrating potential in the treatment of various types of cancer. Its modulation of oncological signaling pathways and molecular targets contributes to its inhibitory effects on tumor growth and progression.
Used in Food Industry:
In the food industry, curcumin is used as a natural coloring agent due to its bright yellow pigment. Its presence in turmeric makes it a popular choice for adding color to various food products, particularly in the preparation of curries and other dishes.
Used in Cosmetics Industry:
Curcumin's anti-inflammatory and antioxidant properties also make it a valuable ingredient in the cosmetics industry, where it is used in the development of skincare products aimed at reducing inflammation and promoting skin health.

Upstream product

• 100-52-7 benzaldehyde 
• 2642-63-9 3',4'-dichloroacetophenone 
• 102-92-1 Cinnamoyl chloride 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 98-86-2 acetophenone 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Downstream Products

• 79325-09-0 6-(3,4-Dichloro-phenyl)-2-oxo-4-phenyl-1,2-dihydro-pyridine-3-carbonitrile 
• 92794-36-0 3-(3,4-Dichlor-benzoyl)-2-phenyl-propionitril 
• 92854-41-6 2-phenyl-4-(3',4'-dichlorophenyl)-4-oxo-butanoic acid 
• 1255771-96-0 tert-butyl 3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-1-carboxylate 
• 1283749-59-6 N-(2-chloro-3-(3,4-dichlorophenyl)-3-oxo-1-phenylpropyl)-4-methylbenzenesulfonamide 
• 1258526-35-0 2-(1-(3,4-dichlorophenyl)-3-phenylallylidene)hydrazinecarboximidamide 
• 116860-08-3 1-(3-(3,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)ethanone 
• 49747-54-8 1-(3',4'-dichlorophenyl)-3-phenyl propanone 
• 106020-47-7 2-Amino-6-(3,4-dichloro-phenyl)-4-phenyl-nicotinonitrile 
• 1300747-61-8 (R)-2-(1-(3,4-dichlorophenyl)-3-oxo-3-phenylpropyl)malononitrile 
• 170939-48-7 (3,4-Dichloro-phenyl)-(4-phenyl-1H-pyrrol-3-yl)-methanol 

Relevant academic research and scientific papers

Synthesis and bioevaluation of thienopyrimidines bearing a pyrazoline unit as selective PI3Kα inhibitors

A series of thienopyrimidines containing a pyrazoline unit (4a-d, 7a-d and 13a-l) were designed and synthesized. The target compounds were evaluated for antiproliferative activity against A549, HepG2 and MCF-7 cancer cell lines. Among the twenty target compounds, most of them exhibited excellent antiproliferative activity against one or several cancer cell lines. Compound 13f showed the best activity against A549, MCF-7 and HepG2 cancer cell lines, with IC50 values of 2.84 ± 0.09 μM, 2.88 ± 0.43 μM and 2.08 ± 0.36 μM, respectively. Four selected compounds (13c, 13f, 13g and 13h) were further evaluated for their inhibitory activity against the PI3Kα/mTOR protein kinase. Moreover, time-dependent and dose-dependent experiments, AO fluorescence staining, Annexin V-FITC/PI staining and docking studies were carried out in this study. The results indicated that compound 13f may be a potential selective PI3Kα inhibitor.

Design, synthesis, and biological evaluation of novel thienopyrimidine derivatives as PI3Kα inhibitors

Three series of novel thienopyrimidine derivatives 9a-l, 15a-l, and 18a-h were designed and synthesized, and their IC50 values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicity against the tested cancer cell lines. The most promising compound 9a showed moderate activity with IC50 values of 12.32 ± 0.96, 11.30 ± 1.19, 14.69 ± 1.32, and 9.80 ± 0.93 μM, respectively. The inhibitory activities of compounds 9a and 15a against PI3Kα and mTOR kinase were further evaluated. Compound 9a exhibited PI3Kα kinase inhibitory activity with IC50 of 9.47 ± 0.63 μM. In addition, docking studies of compounds 9a and 15a were also investigated.

Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl e 2-propen-1-ones

Totally 38 aryl E 2-propen-1-ones including nine substituted styryl 4-iodophenyl ketones have been synthesised using solvent-free SiO 2-H3PO4 catalyzed Aldol condensation between respective methyl ketones and substituted benzaldehydes under microwave irradiation. The yields of the ketones are more than 80%. The synthesised chalcones were characterized by their analytical, physical and spectroscopic data. The spectral frequencies of synthesised substituted styryl 4-iodophenyl ketones have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. The antimicrobial activities of 4-iodophenyl chalcones have been studied using Bauer-Kirby method.

Preheated fly-ash catalyzed aldol condensation: Efficient synthesis of chalcones and antimicrobial activities of some 3-thienyl chalcones

In the present study we have prepared a series of some chalcones using solvent - free Aldol - condensation by microwave irradiation. The yields of the ketones are more than 60%. The synthesised chalcones were characterized by their analytical, physical and spectral data. The antimicrobial activities of substituted styryl 3-thienyl ketones have been studied using Bauer-Kirby method.

Solvent-free synthesis of some1-acetyl pyrazoles

Some N-acetyl pyrazoles including 1-(3-(3,4-dichlorophenyl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-yl) ethanones have been synthesised by solvent free cyclization cum acetylation of chalcones like substituted styryl 3,4-dichlorophenyl

Fly-ash:H2SO4 catalyzed solvent free efficient synthesis of some aryl chalcones under microwave irradiation

Some 2E aryl chalcones have been synthesized using greener catalyst Fly-ash:H2SO4 assisted solvent free environmentally benign Crossed-Aldol reaction. The yields of chalcones are more than 90%. The synthesized chalcones are characterized by their physical constants and spectral data.

Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors

A series of dihydro-pyrazolyl-thiazolinone derivatives (5a-5t) have been synthesized and their biological activities were also evaluated as potential cyclooxygenase-2 (COX-2) inhibitors. Among these compounds, compound 2-(3-(3,4-dimethylphenyl)-5-phenyl-4

Synthesis, molecular modeling and biological evaluation of chalcone thiosemicarbazide derivatives as novel anticancer agents

A series of novel chalcone thiosemicarbazide derivatives (4a-4x) have been designed, synthesized, structurally determined, and their biological activities were also evaluated as potential EGFR kinase inhibitors. All the synthesized compounds are first reported. Among the compounds, compound 4r showed the most potent biological activity (IC50 = 0.78 ± 0.05 μM for HepG2 and IC50 = 0.35 μM for EGFR), which is comparable to the positive controls. Docking simulation was also performed to position compound 4r into the EGFR active site to determine the probable binding model. Antiproliferative assay results demonstrated that some of these compounds possessed good antiproliferative activity against HepG2. Compound 4r with potent inhibitory activity in tumor growth inhibition may be a potential anticancer agent.

Synthesis and insect antifeedant activities of some substituted styryl 3,4-dichlorophenyl ketones

Sixteen substituted styryl 3,4-dichlorophenyl ketones [(2E)-1-(3,4-dichlorophenyl)-3-phenyl-2-propen-1-ones] were synthesized using eco-friendly benign stereoselective crossed-aldol reaction. They are characterized by their analytical, infrared, NMR and m

Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents

A series of novel dithiocarbamate compounds with the chalcone scaffold have been designed and synthesized, and their biological activities were also evaluated as potential antiproliferation and antitubulin polymerization inhibitors. Compound 2n showed the most potent biological activity in vitro, which inhibited the growth of MCF-7 cells with IC50 of 0.04 ± 0.01 μM and the polymerization of tubulin with IC50 of 6.8 ± 0.6 μM. To understand the tubulin-inhibitor interaction and the selectivity of the most active compound towards tubulin, molecular modeling studies were performed to dock compound 2n into the colchicine binding site, which suggested probable inhibition mechanism.