116897-56-4Relevant academic research and scientific papers
Synthesis of 3-alkoxy/aryloxy - Lactams using diazoacetate esters as ketene precursors under photoirradiation
Qi, Hengzhen,Yang, Zhanhui,Xu, Jiaxi
experimental part, p. 723 - 730 (2011/04/24)
3-Alkoxy/aryloxy - lactams are synthesized in satisfactory to good yields from the reaction of imines and alkyl/aryl di-azoacetates under photoirradiation conditions. Typically, trans - lactams are obtained as the major products from linear imines using the current method. By contrast, the corresponding thermal reaction of imines and alkoxy/aryloxyacetyl chlorides, or their equivalents, in the presence of triethylamine affords cis - lactams as the major or exclusive products. The formation of trans - lactams from linear imines is attributed to isomerization of the imines from their trans-isomers into syn-isomers under UV irradiation. The reported method represents a metal-free and neutral approach for the synthesis of 3-alkoxy/aryloxy - lactams. Georg Thieme Verlag Stuttgart New York.
Stereospecific synthesis of azeto[2,1-d]-[1,5]benzothiazepin/diazepin-1-ones
Huang, Xu,Xu, Jiaxi
, p. 564 - 569 (2007/10/03)
2a,4-Disubstituted 2-phenoxy-2,2a,3,4-tetrahydro-1H-azeto[2,1-d][1,5]benzothiazepin-1-ones and 5-benzoyl-2-phenoxy-2a,3,4,5-tetrahydro-azeto[1,2-a][1,5]benzodiazepin-1(2H)-one s were synthesized in moderate to good yields by stereospecific Staudinger cycloaddition reactions of 2,4-disubstituted 2,3-dihydro-1,5-benzothiazepines and 1-benzoyl-2,3-dihydro-1H-1,5-benzodiazepines, respectively, with phenoxy acetyl chloride in the presence of triethylamine in anhydrous benzene.
