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105628-07-7

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Fasudil hydrochloride CAS 105628-07-7 HIGH QUALITY SUPPLY BY FACTORY
Cas No: 105628-07-7
USD $ 1.0-1.0 / Kilogram 1 Kilogram 1 Metric Ton/Day Sparrow Chemical Co.,Ltd Contact Supplier
Fasudil Hydrochloride
Cas No: 105628-07-7
No Data 1 Kilogram inquiry by mail Kilogram/Year Chengdu Sino-Strong Pharmaceutical Co.,Ltd. Contact Supplier
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No Data 10 Gram 200 Kilogram/Week Hubei Jusheng Technology Co., Ltd., Contact Supplier
CAS:105628-07-7 Fasudil hydrochloride
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No Data 1 Kilogram 100 Kilogram/Month Kono Chem Co.,Ltd Contact Supplier
High purity Fasudil?Hydrochloride CAS:105628-07-7
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USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
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USD $ 7.5-10.0 / Gram 100 Gram 100 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
Fasudil Hydrochloride
Cas No: 105628-07-7
No Data 1 Kilogram 20 Metric Ton/Year Henan Allgreen Chemical Co.,Ltd Contact Supplier
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No Data No Data No Data Simagchem Corporation Contact Supplier
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105628-07-7 Usage

Warnings and Precautions

Patients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.

Adverse reactions

Adverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.

Uses

vasodilator, potent Rho-kinase inhibitor

Mechanisms of Action

Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.

Indications and Usage

Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
InChI:InChI=1/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H

105628-07-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (F0839)  Fasudil Hydrochloride  >98.0%(HPLC) 105628-07-7 100mg 1,490.00CNY Detail

105628-07-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Fasudil Hydrochloride

1.2 Other means of identification

Product number -
Other names 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:105628-07-7 SDS

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