1169867-84-8

Upstream product

• 1169867-76-8 (Z)-3-(4-chloroanilino)-1-(2-chlorophenyl)-3-phenylprop-2-en-1-one 
• 1169867-56-4 (Z)-1-(2-bromophenyl)-3-(4-chloroanilino)-3-phenylprop-2-en-1-one 
• 2142-69-0 2-bromophenyl methyl ketone 
• 106-47-8 4-chloro-aniline 
• 100-52-7 benzaldehyde 
• 108237-92-9 1-(2-bromophenyl)-3-phenylprop-2-en-1-one 
• 134419-77-5 1-(2-bromophenyl)-3-phenylprop-2-yn-1-one 

Relevant academic research and scientific papers

One-Pot Synthesis of Quinolin-4(1 H)-one Derivatives by a Sequential Michael Addition-Elimination/Palladium-Catalyzed Buchwald-Hartwig Amination Reaction

A convenient approach has been developed for the construction of quinolin-4(1H)-one frameworks, starting from (Z)-β-chlorovinyl aromatic ketones and amines. Intermolecular Michael addition of an amine to a (Z)-β-chlorovinyl ketone was followed by eliminat

Buchwald-Hartwig coupling/Michael addition reactions: One-pot synthesis of 1,2-disubstituted 4-quinolones from chalcones and primary amines

The Buchwald-Hartwig coupling/Michael addition sequence has been successfully applied to the synthesis of functionalized 1,2-disubstituted 4-quinolones using Pd(OAc)2 as a catalyst and PPh3 as a ligand. Under these conditions, the intermediate products first formed from chalcones and primary amines underwent catalytic dehydrogenation to yield the 1,2-disubstituted 4-quinolones. Copyright

Palladium-catalyzed tandem amination reaction for the synthesis of 4-quinolones

(Figure presented) An efficient palladium-catalyzed tandem amlnatlon approach was developed In one step to afford functlonallzed 4-qulnolones In good to excellent ylelds from easlly accessible o-haloaryl acetylenlc ketones and primary amines.

1,2-Disubstituted 4-quinolones via copper-catalyzed cyclization of 1-(2-halophenyl)-2-en-3-amin-1-ones

1,2-Disubstituted 4-quinolones have been prepared via copper-catalyzed heterocyclization of 1-(2-bromophenyl)- and 1-(2-chlorophenyl)-2-en-3-amin-1- ones, readily obtained from α,β-ynones and primary amines. The reaction tolerates a variety of useful functionalities including ester, keto, cyano, and chloro substituents. Quinolone derivatives can also be prepared via a sequential process from α,β-ynones and primary amines, omitting the isolation of the 1-(2-halophenyl)-2-en-3-amin-1-one intermediates. Georg Thieme Verlag Stuttgart.