117-42-0

Basic information

• Product Name: Koch acid
• Synonyms: 8-amino-1,3,6-naphthalenetrisulfonic acid;8-aminonaphthalene-1,3,6-trisulphonic acid;2-Naphthyl;1,3,6-Naphthalenetrisulfonic acid,8-amino-;1-Aminonaphthalene-3,6,8-trisulfonic acid;3,6-Naphthalenetrisulfonic acid, 8-amino-1;6-naphthalenetrisulfonic acid, 8-amino-3;1-AMinonapthelene 3,6,8 trisulfonic acid disodiuM
• CAS NO: 117-42-0
• Molecular Formula: C₁₀H₉NO₉S₃
• Molecular Weight: 383.37476
• EINECS: 204-188-7
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 117-42-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.974
• PKA: -1.62±0.40(Predicted)
• CAS DataBase Reference: Koch acid(CAS DataBase Reference)
• NIST Chemistry Reference: Koch acid(117-42-0)
• EPA Substance Registry System: Koch acid(117-42-0)

Safety Data

• Hazardous Substances Data: 117-42-0(Hazardous Substances Data)

Usage

General Description

Koch acid, also known as (3,5-dimethyl-2-phenylphenyl)acetic acid, is a chemical compound commonly used in the synthesis of pharmaceuticals and organic chemicals. It is a white to off-white solid with a molecular formula of C16H16O2 and a molecular weight of 240.30 g/mol. Koch acid is known for its high stability and low reactivity, making it a suitable reagent for a variety of chemical reactions. Its applications include the preparation of novel drugs, dyes, and other products in the pharmaceutical and chemical industries. Additionally, Koch acid has shown potential as an anti-inflammatory and analgesic agent in preclinical studies, suggesting its therapeutic potential in the field of medicine.

InChI:InChI=1/C10H9NO9S3.3Na/c11-8-3-6(21(12,13)14)1-5-2-7(22(15,16)17)4-9(10(5)8)23(18,19)20;;;/h1-4H,11H2,(H,12,13,14)(H,15,16,17)(H,18,19,20);;;/q;3*+1/p-3

Upstream product

• 7647-01-0 hydrogenchloride 
• 408511-00-2 1,1-dioxo-2H-1λ⁶-naphth[1,8-cd]isothiazole-4,7-disulfonic acid 
• 7664-93-9 sulfuric acid 
• 38267-31-1 8-nitronaphthalene-1,3,6-trisulphonic acid 
• 91-20-3 naphthalene 
• 120-94-5 1-Methylpyrrolidine 
• 86-66-8 naphthalene-1,3,6-trisulfonic acid 

Downstream Products

• 2234-13-1 octachloronaphthalene 
• 1268310-56-0 C₁₉H₁₃Cl₂N₅O₉S₃ 
• 1258000-28-0 C₂₂H₂₃N₇O₉S₃ 
• 1189037-38-4 C₂₃H₂₃NO₁₄S₃ 
• 786696-32-0 C₁₇H₁₄N₂O₁₁S₃ 
• 90-20-0 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 
• 6251-07-6 4-amino-naphthalene-2,7-disulfonic acid 
• 86-66-8 naphthalene-1,3,6-trisulfonic acid 

Relevant articles and documents

Novel environment-friendly production process for preparing amine product and H - acid through silane chemical reduction of several nitro compounds

The invention relates to the field of new materials for fine chemicals, and relates to a reduction reaction of a series of nitro compounds, in particular to m-nitroaniline. Several particular important amine compounds such as m-phenylenediamine, 5 - amino o-cresol, 2 - methyl p-phenylenediamine, 1/2 - naphthylamine, H - acid amine and 2, 4, 6 - trimethyl-M-phenylenediamine are prepared from the corresponding mono-or double-nitro compound precursors with a new environmental protection production process technology of and acids derived from the novel process technology. H.

Synthesis, characterization and RP-HPLC method development and validation for simultaneous determination of Koch acid and H acid

1-amino-8-naphthol-3,6-disulfonic acid (H acid) is an important intermediate used for the synthesizing some dyestuffs and pharmaceuticals. The synthesis of H acid was followed by sulfonation, nitration, reduction and alkali fusion. The total yield was increased to 35% with 99% purity. This study focuses on cheap synthesis of H acid on an industrial scale. The composition and percentage of these compounds were characterized by making reactive dyes and chromatographic analysis, i.e. UV/Visible, IR and HPLC. The RP-HPLC method was developed; in the analysis of Koch acid (1-amino-naphthalene-3,6,8-trisulfonic acid) and H acid. The single HPLC method is useful, both, in the chemical intermediate (Koch acid) and for the final product (H acid).

Chondroitin sulfate as a marker of bone resorption

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