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N,N-dimethyl-3-(2-methyl-10H-phenothiazin-10-yl)propan-1-amine, also known as promethazine, is a phenothiazine derivative with the molecular formula C17H20N2S. It is a widely used antihistamine and antiemetic drug, belonging to the class of phenothiazine antihistamines. Promethazine works by blocking histamine receptors, which helps in reducing symptoms such as itching, runny nose, and sneezing. It is commonly used to treat allergies, motion sickness, and nausea and vomiting associated with various conditions. The drug is available in various forms, including tablets, syrups, and injectable solutions. Promethazine is also known for its sedative and antipsychotic effects, making it useful in the management of anxiety and agitation. However, it is important to note that promethazine can cause side effects such as drowsiness, dizziness, and dry mouth, and its use should be carefully monitored, especially in children and elderly individuals.

117-65-7

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117-65-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 117-65-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 117-65:
(5*1)+(4*1)+(3*7)+(2*6)+(1*5)=47
47 % 10 = 7
So 117-65-7 is a valid CAS Registry Number.

117-65-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-dimethyl-3-(2-methylphenothiazin-10-yl)propan-1-amine

1.2 Other means of identification

Product number -
Other names 10H-Phenothiazine-10-propanamine,N,N,2-trimethyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:117-65-7 SDS

117-65-7Downstream Products

117-65-7Relevant academic research and scientific papers

Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds

Dahl, Troels,Tornoe, Christian W.,Bang-Andersen, Benny,Nielsen, Poul,Jorgensen, Morten

supporting information; scheme or table, p. 1726 - 1728 (2009/02/06)

(Chemical Presented) Zip it up! The use of a Pd/dppf catalyst gives access to the tricyclic phenothiazine scaffold starting from 1-bromo-2-iodobenzenes, aliphatic or aromatic amines, and 2-bromothiophenols in a single reaction flask (see scheme; dppf=1,1′-bis(diphenylphosphanyl) ferrocene; dba=dibenzylidineacetone). This transformation involves thioether formation and subsequent intermolecular and intramolecular aryl amination reactions. The reaction occurs in good overall yield and selectivity.

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