117048-60-9

Basic information

• Product Name: combretastatin A5
• Synonyms: combretastatin A5;(Z)-3',4,4',5-Tetramethoxy-3-hydroxystilbene;2,3-Dimethoxy-5-[(Z)-3,4-dimethoxystyryl]phenol
• CAS NO: 117048-60-9
• Molecular Formula: C18H20 O5
• Molecular Weight: 316.35
• Mol File: 117048-60-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 494.8°Cat760mmHg
• Flash Point: 253.1°C
• Appearance: /
• Density: 1.184g/cm³
• Vapor Pressure: 2.05E-10mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: combretastatin A5(CAS DataBase Reference)
• NIST Chemistry Reference: combretastatin A5(117048-60-9)
• EPA Substance Registry System: combretastatin A5(117048-60-9)

Safety Data

• Hazardous Substances Data: 117048-60-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H20O5/c1-20-15-8-7-12(10-16(15)21-2)5-6-13-9-14(19)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-

Upstream product

• 93828-11-6 1-bromo-3-hydroxy-4,5-dimethoxybenzene 
• 61240-20-8 triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide 
• 185698-57-1 tert-Butyl-[5-(3,4-dimethoxy-phenylethynyl)-2,3-dimethoxy-phenoxy]-dimethyl-silane 
• 185698-56-0 (5-Bromo-2,3-dimethoxy-phenoxy)-tert-butyl-dimethyl-silane 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 71295-21-1 5-bromo-2,3-dimethoxybenzaldehyde 
• 2859-78-1 4-Bromoveratrole 
• 4302-52-7 4-ethynylveratrole 
• 121042-97-5 3'-<(tert-butyldimethylsilyl)oxy>combretastatin A-5 

Relevant articles and documents

Ethynylation of aryl halides by a modified Suzuki reaction: Application to the syntheses of combretastatin A-4, A-5 and lunularic acid

On treatment with trimethyl borate sodium acetylide undergoes a palladium-catalyzed cross coupling with functionalized aryl halides or triflates in reasonable to good yields. The ethynylarenes thus obtained serve as building blocks for the formation of the highly effective tubulin polymerization inhibitors combretastatin A-4 (1) and A-5 (2) as well as for the synthesis of the plant-growth regulator lunularic acid (36). VCH Verlagsgesellschaft mbH, 1996.