1170613-55-4 Usage
Uses
Used in Pharmaceutical Industry:
A-967079 is used as a potential analgesic drug for the treatment of chronic pain. It functions as a TRPA1 antagonist, which can help in managing neuropathic and inflammatory pain conditions.
Used in Pain Research:
A-967079 is used as a research tool for studying the role of TRPA1 channels in pain sensation. By blocking these channels, researchers can gain insights into the underlying mechanisms of pain and develop new therapeutic strategies.
Used in Drug Delivery Systems:
A-967079 has been used in the development of novel drug delivery systems to enhance its applications and efficacy against pain conditions. Various carriers, such as organic and metallic nanoparticles, have been employed to improve the delivery, bioavailability, and therapeutic outcomes of A-967079.
Used in Blocking miR-711-induced TRPA1 Channels:
A-967079 is used as a blocker for miR-711-induced TRPA1 channels, which may have implications in the treatment of pain related to specific genetic or molecular factors.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
References
1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats; Mol. Pain, 6 14.
Check Digit Verification of cas no
The CAS Registry Mumber 1170613-55-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,0,6,1 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1170613-55:
(9*1)+(8*1)+(7*7)+(6*0)+(5*6)+(4*1)+(3*3)+(2*5)+(1*5)=124
124 % 10 = 4
So 1170613-55-4 is a valid CAS Registry Number.
1170613-55-4Relevant academic research and scientific papers
TRPA1 antagonists
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, (2015/09/22)
Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds
TRPA1 Antagonists
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, (2009/07/18)
Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds an
