117155-95-0Relevant academic research and scientific papers
Palladium-catalyzed asymmetric hydrogenolysis of N-sulfonyl aminoalcohols via achiral enesulfonamide intermediates
Yu, Chang-Bin,Zhou, Yong-Gui
supporting information, p. 13365 - 13368 (2014/01/06)
Giving the cat complete control: A stereoconvergent formal hydrogenolysis of N-sulfonyl aminoalcohols in the presence of a chiral Pd catalyst and trifluoroacetic acid (TFA) gave chiral amines with two contiguous stereocenters (see scheme; TFE=trifluoroethanol, Ts=p-tosyl). The products were formed with up to 94 %ee by acid-catalyzed dehydration to afford an enesulfonamide, enamine/imine isomerization, and Pd-catalyzed asymmetric hydrogenation.
trans-(1S,2S)-1-substituted-2-(N,N-dialkylamino)-1-indanol derivatives as chiral ligands in the catalytic enantioselective addition of diethylzinc to aldehydes
Xu, Qianyong,Yang, Hongfang,Pan, Xinfu,Chan, Albert S.C.
, p. 945 - 951 (2007/10/03)
A series of optically active trans-(1S,2S)-1-substituted-2-(N,N-dialkylamino)-1-indanol derivatives 1-6 were synthesized and applied in the catalytic enantioselective addition of diethylzinc to aldehydes. The enantiomeric purity of the addition products i
