19887-32-2

Basic information

• Product Name: N-ETHOXYCARBONYL-L-PHENYLALANINE
• Synonyms: N-ALPHA-ETHOXYCARBONYL-L-PHENYLALANINE;N-ETHOXYCARBONYL-L-PHENYLALANINE;N-Ethoxycarbonyl-3-phenyl-L-alanine;ETOC-PHE-OH
• CAS NO: 19887-32-2
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 19887-32-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 78-82 °C(lit.)
• Boiling Point: 419oC at 760 mmHg
• Flash Point: 207.2oC
• Appearance: /
• Density: 1.213g/cm3
• Vapor Pressure: 9.06E-08mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.56±0.10(Predicted)
• CAS DataBase Reference: N-ETHOXYCARBONYL-L-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ETHOXYCARBONYL-L-PHENYLALANINE(19887-32-2)
• EPA Substance Registry System: N-ETHOXYCARBONYL-L-PHENYLALANINE(19887-32-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 19887-32-2(Hazardous Substances Data)

Usage

General Description

N-Ethoxycarbonyl-L-phenylalanine, also known as N-ethoxycarbonylphenylalanine, is a compound that is commonly used in the field of chemistry and biochemistry. It is an amino acid derivative that is often employed in the synthesis of peptides and other organic compounds. The "N-ethoxycarbonyl" group is often used as a protective group for the amine group of the amino acid, allowing for selective reactions at other functional groups. N-ETHOXYCARBONYL-L-PHENYLALANINE is used in various research and industrial applications, making it an important tool in the development of new pharmaceuticals, materials, and other products.

InChI:InChI=1/C12H15NO4/c1-2-17-12(16)13-10(11(14)15)8-9-6-4-3-5-7-9/h3-7,10H,2,8H2,1H3,(H,13,16)(H,14,15)/t10-/m0/s1

Upstream product

• 63-91-2 L-phenylalanine 
• 541-41-3 chloroformic acid ethyl ester 
• 63-91-2 L-phenylalanine 
• 151418-18-7 Aethoxykohlensaeure-dihydrozimtsaeure-anhydrid 
• 70930-37-9 N-(Ethyloxycarbonyl)-L-Phe-p-nitrophenyl ester 
• 74877-64-8 ethyl α-methoxyvinyl carbonate 

Downstream Products

• 55740-08-4 4-benzyl-5-oxo-oxazolidine-3-carboxylic acid ethyl ester 
• 117161-18-9 (S)-2-((S)-2-Ethoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoic acid methyl ester 
• 403860-20-8 (S)-2-phenyl-1-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine 
• 1365842-07-4 cis-N-(1-butyl-2,3-dihydro-1H-inden-2-yl)-4-methylbenzenesulfonamide 
• 1290608-14-8 Eoc-L-Phe-ψ[NHCONH]-L-Phg-OMe 
• 1290608-13-7 Eoc-L-Phe-ψ[NHCONH]-L-Glu-(OMe)2 
• 1290608-12-6 Eoc-L-Phe-ψ[NHCONH]-L-Leu-OMe 
• 1279636-74-6 1-[1-(ethoxycarbonylamino)-2-phenylethyl-carbamoyl]-4-[1-(ethoxycarbonylamino)-2-phenylethyl]semicarbazide 
• 1279636-39-3 4-[1-(ethoxycarbonylamino)-2-phenylethyl]semicarbazide 
• 1020082-43-2 C₁₂H₁₅N₅O₃ 
• 1000611-84-6 methyl (S)-1-[(S)-1-(2-ethylthiazole-4-yl)-2-(4-nitrophenyl)ethyl]amino-1-oxo-3-phenylpropane-2-ylcarbamate 

Relevant articles and documents

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approac

Practical synthesis of fluorous oxazolidinone chiral auxiliaries from α-amino acids

A series of new fluorous-supported oxazolidinone chiral auxiliaries has been prepared using a versatile and general five-step pathway, starting from readily available chiral α-amino acids. The key feature of this synthesis is the efficient generation of a suitably active perfluoroalkyllithium species. By use of this protocol, the auxiliaries can be obtained in high enantiomeric purity and on multigram scales from L-phenylalanine and L-valine with overall yields as high as 55%. The new methodology also incorporates fluorous solid-phase extraction on the large scale, allowing bulk quantities (up to 25 g) of fluorous compounds to be purified from the crude reaction mixture.

'One-pot' synthesis of chiral N-protected α-amino acid-derived 1,2,4-oxadiazoles

A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via an easy, inexpensive and one-pot protocol. The heterocycles were obtained in good yields and in relatively short reaction times.