117204-61-2

Downstream Products

• 477252-03-2 N-Cyclopropyl-1-[3-(4-sulfamoylphenyl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide 
• 477252-32-7 N-Cyclopropyl-1-{5-bromo-3-[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]phenyl}-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide 
• 98907-91-6 β-(N-benzyl-N-methylamino)-ethyl 5-(3,6-dimethyl-1-oxo-1-phospha-2,7-dioxacycloheptyl)-2,6-dimethyl-1,4-dihydro-4-(3-nitrophenyl)pyridine-3-carboxylate 
• 119035-22-2 1-(1-oxo-1,2,3,4-tetrahydro-6-naphthoyl)-4-(3,4,5-trimethoxybenzyl)piperazine hydrochloride 
• 122186-87-2 ethyl N-[2-(4-acetamidobutyryl)-5-chlorohydrocinnamoyl]glycinate 
• 122187-20-6 ethyl N-[2-[4-(4-acetamidobutyramido)butyryl]-5-chlorohydrocinnamoyl]glycinate 
• 42573-57-9 2-(4-methoxystyryl)-4,6-bis(trichloromethyl)-1,3,5-triazine 
• 39925-12-7 methyl 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxylate 
• 408366-92-7 4'-(2-hydroxyethoxy)-N-(4-{[2-(2-pyridinyl)ethyl]amino}phenyl)-1,1'-biphenyl-2-carboxamide 
• 888741-29-5 3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-5-[(2,4-dichlorophenoxy)methyl]phenol 
• 87476-76-4 N-[3-[3-(4-morpholinylmethyl)phenoxy]propyl]-1,2-benzisothiazol-3-amine 1,1-dioxide hydrochloride 
• 104121-25-7 2-amino-6-(o-nitrophenoxy)purine 
• 68282-18-8 5-methyl-2-phenethyl-7-propyl-1⁽³⁾,4-dihydro-imidazo[5,1-f][1,2,4]triazine 
• 68282-02-0 5-methyl-2-phenethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 

Relevant academic research and scientific papers

Condensed pyridazine derivatives, their production and use

A condensed pyridazine derivative which is useful as a pharmaceutical composition for preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria and prurigo.

Condensed pyridazine derivatives, their production and use

The present invention provides a compound represented by the formula: wherein Ar1 and Ar2 are independently an aromatic group which may be substituted, and Ar1 and Ar2 may form a condensed cyclic group with an adjacent carbon atom; ring B is a nitrogen-containing heterocycle which may be substituted; X and Y are the same or different and are independently a bond, an oxygen atom, S(O)p (p is an integer of 0 ot 2), NR4 wherein R4 is a hydrogen atom or a lower alkyl group, or a bivalent linear lower hydrocarbon group which may contain 1 to 3 hetero atoms and the bivalent linear lower hydrocarbon group may be substituted; A is a nitrogen atom or CR7 wherein R7 is a hydrogen atom, a halogen atom, a hydrocarbon which may be substituted, an acyl group or a hydroxy group which may be substituted; R1, R2 and R3 are the same or different and are independently a hydrogen atom, a halogen atom, a hydrocarbon group which may be substituted, an acyl group or a hydroxy group which may be substituted; R8 is a hydrogen atom, a hydroxy group which may be substituted by a lower alkyl or a carboxyl group, or a salt thereof, which exhibits excellent anti-histaminic or eosinophil chemotaxis-inhibiting activities and is useful in treatment or prevention of asthma, allergic conjunctivitis, allergic rhinitis, chronic urticaria or atopic dermatitis.