117238-30-9Relevant academic research and scientific papers
Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplexes Formed with their RNA and DNA Complements
De Mesmaeker, Alain,Lebreton, Jacques,Jouanno, Chantal,Fritsch, Valérie,Wolf, Romain M.,Wendeborn, Sebastian
, p. 1287 - 1290 (2007/10/03)
The amide backbone modification C3′-CH2-CONH-C5′ has been further modified by introducing a methyl at C5′, either in R or in S configuration. Only the S stereoisomer can adopt the required geometry to fit into a duplex with complementary RNA. A
Method of inhibiting virus
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, (2008/06/13)
A group of five- and six-membered heterocyclic compounds having a nitrogen in the ring and 2 to 3 hydroxyl substituents on the ring are effective inhibitory agents of human immunodeficiency virus.
