117252-05-8Relevant articles and documents
Protecting-group-free synthesis of hydroxyesters from amino alcohols
Joseph-Valcin, Eve-Marline,Lebel, Hélène,Reynard, Guillaume
supporting information, p. 10938 - 10941 (2020/10/02)
The synthesis of hydroxyesters from carboxylic acids and unprotected amino alcohols in both continuous flow and batch processes is reported. The formation of a transient diazonium species with a dinitrite reagent is key in this transformation. The reaction conditions are compatible with a variety of functional groups.
RORGAMMA MODULATORS AND USES THEREOF
-
Page/Page column 41; 51, (2018/08/20)
The present invention provides novel compounds of formula (la) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases, or cholestatic diseases.
Efficient phosphonium-mediated synthesis of 2-amino-1,3,4-oxadiazoles
Levins, Christopher G.,Wan, Zhao-Kui
supporting information; experimental part, p. 1755 - 1758 (2009/04/12)
We present an efficient, room temperature procedure for the preparation of 2-amino-1,3,4-oxadiazoles. Oxadiazol-2-ones can be activated for SnAr substitution using phosphonium reagents (e.g., BOP). This approach provides convenient access to N,