1172582-40-9Relevant academic research and scientific papers
Highly selective ratiometric fluorescent sensing for Hg2+ and Au3+, respectively, in aqueous media
Dong, Ming,Wang, Ya-Wen,Peng, Yu
, p. 5310 - 5313 (2010)
A nonsulfur probe based on a 1,8-naphthalimide and alkyne conjugate for the ratiometric fluorescent sensing for Hg2+ and Au3+ through the tuning of pH in different aqueous solutions is described. This work provides a novel reaction-based approach for selective recognition of these two ions with significant change of fluorescence color and constitutes the first ratiometric case for Au3+.
Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress
Wi, Youngjin,Le, Hoa Thi,Verwilst, Peter,Sunwoo, Kyoung,Kim, Seo Jin,Song, Jung Eun,Yoon, Hey Young,Han, Geon,Kim, Jong Seung,Kang, Chulhun,Kim, Tae Woo
, p. 8897 - 8900 (2018)
We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to GSH over thioredoxin, a potent competitor, were clearly demonstrated, both in solution and in vitro. Finally, a confocal microscopic investigation revealed that GSH levels in the ER were dramatically decreased under thapsigargin, brefeldin A, and tunicamycin-induced ER stress models.
A hepatocyte-targeting fluorescent probe for imaging isoniazid-induced hydrazine in HepG2 cells and zebrafish
Guo, Zhenbo,Wang, Mei,Li, Xueyan,Jia, Xu,Wang, Xiaoli,Zhang, Pingzhu,Wei, Chao,Li, Xiaoliu
, p. 14183 - 14186 (2020)
A hepatocyte-targeting fluorescent N2H4 probe, GHP, was first designed and synthesized employing N-acetylgalactosamine (GalNAc) as the hepatocyte-targeting group and 3-nitrophthalimide as the recognition moiety. The probe can be used to selectively image N2H4 produced by the hydrolysis of isoniazid in HepG2 cells and the liver of zebrafish in situ. This journal is
Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'
Calatrava-Pérez, Elena,Bright, Sandra A.,Achermann, Stefan,Moylan, Claire,Senge, Mathias O.,Veale, Emma B.,Williams, D. Clive,Gunnlaugsson, Thorfinnur,Scanlan, Eoin M.
, p. 13086 - 13089 (2016/11/09)
Glycosylated 4-amino-1,8-naphthalimide derivatives possess a native glycosidic linkage that can be selectively hydrolysed in situ by glycosidase enzymes to release the naphthalimide as a fluorescent imaging or therapeutic agent. In vitro studies using a variety of cancer cell lines demonstrated that the naphthalimides only get taken up into cells upon enzymatic cleavage from the glycan unit; a mechanism that offers a novel approach for the targeted delivery of probes/drugs.
Clickable fluorophores for biological Labeling - With or without copper
Kele, Peter,Li, Xiaohua,Link, Martin,Nagy, Krisztina,Herner, Andras,Lrincz, Krisztian,Beni, Szabolcs,Wolfbeis, Otto S.
supporting information; experimental part, p. 3486 - 3490 (2010/01/06)
The synthesis of a set of new clickable fluorophores that virtually cover the whole visible spectrum reaching the near infra-red regime is presented herein. Besides dyes that are capable of participating in classical copper catalyzed 1,3-dipolar cycloaddition reactions with the counterparting function we have also prepared dyes containing a cyclooctyne moiety, an alkyne derivative that enables copper free clicking to azides. The suitability of these dyes for fluorescent labeling of biomolecules is presented by examples on model frameworks representing major biopolymer building blocks. The versatility of these dyes is presented in cell labeling experiments as well as by labeling the azide modified surface glycans of CHO-cells either by copper catalyzed or copper-free click reaction. These dyes are expected to have a large variety of applications in (bio)orthogonal labeling schemes both in vivo and in vitro.
