117309-46-3

Usage

Uses

Used in Organic Synthesis:
2-([(4-Methoxyphenyl)sulfonyl]amino)-2-phenylacetic acid is used as a building block for the synthesis of more complex organic molecules. Its versatile functional groups allow for various chemical reactions, making it a valuable intermediate in the preparation of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-([(4-Methoxyphenyl)sulfonyl]amino)-2-phenylacetic acid is used as a potential active pharmaceutical ingredient (API) or as a key intermediate in the synthesis of APIs. Its unique structure and reactivity may contribute to the development of new drugs with novel mechanisms of action or improved pharmacokinetic properties.
Used in Materials Science:
2-([(4-Methoxyphenyl)sulfonyl]amino)-2-phenylacetic acid is used as a component in the development of new materials with specific properties. Its aromatic and acidic characteristics may be exploited to create materials with tailored electronic, optical, or mechanical properties for applications in areas such as electronics, sensors, and advanced materials.

InChI:InChI=1/C15H15NO5S/c1-21-12-7-9-13(10-8-12)22(19,20)16-14(15(17)18)11-5-3-2-4-6-11/h2-10,14,16H,1H3,(H,17,18)/p-1/t14-/m1/s1

Upstream product

• 2935-35-5 (S)-2-phenylglycine 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Relevant academic research and scientific papers

Highly enantioselective aza Morita-Baylis-Hillman reaction catalyzed by bifunctional β-isocupreidine derivatives

The aza-MBH reaction of imines 1 and β-naphthyl acrylate 2 in the presence of C-6′ modified β-isocupreidine derivative 1c (0.1 equiv) and β-naphthol 5 (0.1 equiv) afforded the corresponding (3S)-aza-MBH adducts 4 in high yield and excellent enantiomeric excess. These catalytic conditions allowed the aliphatic imines to be employed for the first time as electrophilic partners of the aza-MBH reaction. The coexistence of two H-bond donors with different acidic strengths was found to be crucial for the observed high enantioselectivity. Copyright

N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase

A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.