117309-49-6

Basic information

• Product Name: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID
• Synonyms: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID;2-(4-FLUOROBENZENESULPHAMIDO)-2-PHENYLACETIC ACID;2-(4-FLUOROBENZENESULFAMIDO)-2-PHENYLACETIC ACID;N-(4-FLUOROBENZENESULFONYL)PHENYLGLYCINE;2-(4-FluorophenylsulfonaMido)-2-phenylacetic acid;2-(4-Fluorobenzenesulphamido)-2-phenylaceticacid97%
• CAS NO: 117309-49-6
• Molecular Formula: C₁₄H₁₂FNO₄S
• Molecular Weight: 309.31
• Mol File: 117309-49-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 179-181°C
• Boiling Point: 490.4°Cat760mmHg
• Flash Point: 250.4°C
• Appearance: /
• Density: 1.426g/cm³
• Vapor Pressure: 1.96E-10mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 2.80±0.10(Predicted)
• CAS DataBase Reference: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID(117309-49-6)
• EPA Substance Registry System: 2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID(117309-49-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 117309-49-6(Hazardous Substances Data)

Usage

General Description

"2-([(4-FLUOROPHENYL)SULFONYL]AMINO)-2-PHENYLACETIC ACID" is an organic chemical compound known for its complex structure. The compound's structure is characterized by the bond of a fluorophenyl group through a sulfonyl linkage to an amino acid, specifically 2-phenylacetic acid. A fluorophenyl group refers to a phenyl group (a functional group composed of six carbon atoms attached to something else) containing one or more fluorine atoms. As a sulfonyl compound, it contains a specific sequence of atoms characterized by a sulfur atom linked to two oxygen atoms. Though it doesn't appear to be widely used in the general or industrial chemistry, detailed information regarding any very specific applications, reactions or safety measures is not commonly available.

InChI:InChI=1/C14H12FNO4S/c15-11-6-8-12(9-7-11)21(19,20)16-13(14(17)18)10-4-2-1-3-5-10/h1-9,13,16H,(H,17,18)/p-1/t13-/m1/s1

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 2935-35-5 (S)-2-phenylglycine 

Relevant articles and documents

N- and 2-Substituted N-(Phenylsulfonyl)glycines as Inhibitors of Rat Lens Aldose Reductase

A variety of N-(phenylsulfonyl)-N-phenylglycines 5, N-(phenylsulfonyl)-2-phenylglycines 6, and N-(phenylsulfonyl)anthranilic acids 7 were prepared as analogues of the N-(phenylsulfonyl)glycine 1 aldose reductase inhibitors.In the rat lens assay, several derivatives of 5 display greater inhibitory activity than the corresponding glycines 1, suggesting that N-phenyl substitution enhances affinity for aldose reductase.Enzyme kinetic evaluations of the 4-benzoylamino analogues of 5 and 1 demonstrate that these compounds produce inhibition by the same mechanism.However, the significant differences in relative inhibitory potencies between compounds of series 5 and 1 may indicate that these compounds do not interact with the inhibitor binding site in precisely the same manner.Evaluation of the individual enantiomers of series 6 reveals that the S isomers are substantially more active than the corresponding R isomers.Also, with the exception of the naphthalene analogue 6n, the S stereoisomers of this series display greater inhibitory potencies than the glycines 1.The anthranilates 7 generally are less active than the glycines 1, demonstrating that direct incorporation of an aromatic ring in the glycine side chain may result in a decrease in affinity for aldose reductase.