1173435-64-7 Usage
Biochem/physiol Actions
BMS-665053 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 10 μM against 150 pM ovine CRF in binding assay). BMS-665053 exhibits anxiolytic efficacy in a defensive withdrawal anxiety test in rats in vivo (10 mg/kg p.o.) with good oral bioavailability (F = 52%).
Check Digit Verification of cas no
The CAS Registry Mumber 1173435-64-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,3,4,3 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1173435-64:
(9*1)+(8*1)+(7*7)+(6*3)+(5*4)+(4*3)+(3*5)+(2*6)+(1*4)=147
147 % 10 = 7
So 1173435-64-7 is a valid CAS Registry Number.
1173435-64-7Relevant articles and documents
An efficient, direct bis-ortho-chlorination of 4-(difluoromethoxy)aniline and its application to the synthesis of BMS-665053, a potent and selective pyrazinone-containing corticotropin-releasing factor-1 receptor antagonist
Li, Jianqing,Smith, Daniel,Krishnananthan, Subramaniam,Hartz, Richard A.,Dasgupta, Bireshwar,Ahuja, Vijay,Schmitz, William D.,Bronson, Joanne J.,Mathur, Arvind,Barrish, Joel C.,Chen, Bang-Chi
experimental part, p. 156 - 159 (2012/05/20)
An efficient scale-up synthesis of (S)-5-chloro-1-(1-cyclopropylethyl)-3- (2,6-dichloro-4-(difluoromethoxy)phenylamino)-pyrazin-2(1H)-one, 1 (BMS-665053), is described. This new process features a one-step direct bis-ortho- chlorination of 4-(difluorometh
