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1173435-64-7

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1173435-64-7 Usage

Biochem/physiol Actions

BMS-665053 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 10 μM against 150 pM ovine CRF in binding assay). BMS-665053 exhibits anxiolytic efficacy in a defensive withdrawal anxiety test in rats in vivo (10 mg/kg p.o.) with good oral bioavailability (F = 52%).

Check Digit Verification of cas no

The CAS Registry Mumber 1173435-64-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,3,4,3 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1173435-64:
(9*1)+(8*1)+(7*7)+(6*3)+(5*4)+(4*3)+(3*5)+(2*6)+(1*4)=147
147 % 10 = 7
So 1173435-64-7 is a valid CAS Registry Number.

1173435-64-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-Chloro-1-[(1S)-1-cyclopropylethyl]-3-{[2,6-dichloro-4-(difluoro methoxy)phenyl]amino}-2(1H)-pyrazinone

1.2 Other means of identification

Product number -
Other names 1-Boc-D-Pyroglutamic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1173435-64-7 SDS

1173435-64-7Downstream Products

1173435-64-7Relevant academic research and scientific papers

An efficient, direct bis-ortho-chlorination of 4-(difluoromethoxy)aniline and its application to the synthesis of BMS-665053, a potent and selective pyrazinone-containing corticotropin-releasing factor-1 receptor antagonist

Li, Jianqing,Smith, Daniel,Krishnananthan, Subramaniam,Hartz, Richard A.,Dasgupta, Bireshwar,Ahuja, Vijay,Schmitz, William D.,Bronson, Joanne J.,Mathur, Arvind,Barrish, Joel C.,Chen, Bang-Chi

experimental part, p. 156 - 159 (2012/05/20)

An efficient scale-up synthesis of (S)-5-chloro-1-(1-cyclopropylethyl)-3- (2,6-dichloro-4-(difluoromethoxy)phenylamino)-pyrazin-2(1H)-one, 1 (BMS-665053), is described. This new process features a one-step direct bis-ortho- chlorination of 4-(difluorometh

In vitro intrinsic clearance-based optimization of N3- phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists

Hartz, Richard A.,Ahuja, Vijay T.,Rafalski, Maria,Schmitz, William D.,Brenner, Allison B.,Denhart, Derek J.,Ditta, Jonathan L.,Deskus, Jeffrey A.,Yue, Eddy W.,Arvanitis, Argyrios G.,Lelas, Snjezana,Li, Yu-Wen,Molski, Thaddeus F.,Wong, Harvey,Grace, James E.,Lentz, Kimberley A.,Li, Jianqing,Lodge, Nicholas J.,Zaczek, Robert,Combs, Andrew P.,Olson, Richard E.,Mattson, Ronald J.,Bronson, Joanne J.,Macor, John E.

experimental part, p. 4161 - 4172 (2010/02/28)

A series of pyrazinone-based heterocycles was identified as potent and orally active corticotropinreleasing factor-1 (CRF1) receptor antagonists. Selected compounds proved efficacious in an anxiety model in rats; however, pharmacokinetic proper

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