117375-15-2

Usage

Uses

Used in Chemical Research:
1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-, methyl ester (9CI) is used as a research compound for studying its chemical properties and potential applications in various chemical processes.
Used in Pharmaceutical Development:
1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-, methyl ester (9CI) is used as a pharmaceutical intermediate for the development of new drugs, given its unique structure and potential interactions with biological systems.
Used in Drug Synthesis:
1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-, methyl ester (9CI) is used as a key component in the synthesis of various pharmaceutical compounds, leveraging its esterification and hydrogen bonding capabilities.
Used in Analytical Chemistry:
1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-, methyl ester (9CI) is used as an analytical standard or reference compound in various analytical techniques, such as chromatography and spectroscopy, to ensure accurate measurements and comparisons.
Note: The specific applications mentioned above are hypothetical and provided as examples, as the provided materials do not detail the exact uses of 1H-Pyrrolizine-7a(5H)-carboxylic acid, tetrahydro-, methyl ester (9CI). Further research is needed to explore its properties and potential applications in various industries.

Upstream product

• 117375-13-0 9,9-dimethoxy-5-phenylthio-1-azabicyclo<3.3.1>nonane 
• 145681-01-2 (+/-)-N-tert-butoxycarbonylproline methyl ester 
• 909076-34-2 1-(tert-butyl) 2-methyl 2-(3-chloropropyl)pyrrolidine-1,2-dicarboxylate 
• 474010-94-1 methyl (2S)-2-(3-bromopropyl)-N-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate 
• 107861-62-1 5,9,9-trichloro-1-azabicyclo<3.3.1>nonane 
• 107861-60-9 7a-trichloromethyl-2,3,5,6,7,7a-hexahydro-1H-pyrrolizine 
• 115909-40-5 9,9-dichloro-5-phenylthio-1-azabicyclo<3.3.1>nonane 

Downstream Products

• 474010-98-5 5-azabicyclo[3.3.0]octanecarboxaldehyde 

Relevant academic research and scientific papers

QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF

Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

FIVE-MEMBERED HETEROAROMATIC OLEFINIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NCOTINIC CHOLINERGIC RECEPTORS

The present invention relates to five-membered heteroaromatic olefinic azacyclic compounds and five-membered heteroaromatic acetylenic azacylic compounds, having formula (I) wherein the ring including X, XI, XII, XIII and X IV is heteroaromatic, B is a two-carbon bridging species and Q, E, EI, EII, EIII, m and n are as defined herein and pharmaceutical compositions containing them that are capable of affecting nicotic cholinergic receptors.

Pharmaceutical compositions and methods for use

The present invention relates to aryl olefinic azacyclic compounds and aryl acetylenic azacylic compounds. The present invention relates in particular to five-membered heteroaromatic olefinic azacyclic compounds and five-membered heteroaromatic acetylenic azacylic compounds, including isoxazolyl olefinic cycloalkylamines and isoxazolyl acetylenic cycloalkylamines.

Synthesis of 5,9,9-Trisubstituted 1-Azabicyclononanes and their Conformational Analyses

A new route for the preparation of 1-azabicyclononane (1) and related compounds, consisting of the reactions similar to the skeletal rearrangement of 2,3,5,6,7,7a-hexahydro-7a-trichloromethylpyrrolizine (2) into 5,9,9-trichloro-1-azabicyclononane (3), is described.The comformational analysis and some chemical properties of the products are also mentioned.