1174281-25-4Relevant academic research and scientific papers
Copper-assisted preparation of pyridinyl sulfonate esters from hydroxypyridines and sodium sulfinates
Fan, Qiangwen,Le, Zhang-Gao,Li, Qian,Liu, Yishuai,Xie, Zongbo,Yang, Liu,Zhu, Haibo
, p. 2736 - 2740 (2022/02/09)
An efficient and powerful copper-assisted method for the effective conversion of a broad range of hydroxypyridines and sodium sulfinates into their corresponding pyridinyl tosylates was developed. Key features of this base- and ligand-free protocol include using the cheap and readily available CuBr2 as a medium and the use of sodium sulfinates as formal sulfonylation reagents. A variety of functional pyridinyl tosylates could be formed with good yields, which can easily be converted into C-C and C-N bond-containing compounds. This journal is
A new one-pot solvent-free synthesis of pyridinyl tosylates via diazotization of aminopyridines
Tretyakov, Alexey N.,Krasnokutskaya, Elena A.,Gorlushko, Dmitry A.,Ogorodnikov, Vladimir D.,Filimonov, Victor D.
supporting information; experimental part, p. 85 - 87 (2011/02/25)
A new, convenient, one-pot method for the synthesis of pyridinyl tosylates is developed. The procedure involves sequential diazotization/tosylation of aminopyridines with sodium nitrite and p-toluenesulfonic acid under solvent-free conditions in a water p
Heteroaromatic tosylates as electrophiles in regioselective Mizoroki-Heck-coupling reactions with electron-rich olefins
Gogsig, Thomas M.,Lindhardt, Anders T.,Dekhane, Mouloud,Grouleff, Julie,Skrydstrup, Troels
supporting information; experimental part, p. 5950 - 5955 (2010/02/28)
Heteroaromatic 2-pyridyl tosylates were successfully applied as electrophiles in palladium(0)-catalyzed Mizoroki-Heck-coupling reactions to electron-rich olefins with complete aregioselectivity. This protocol represents a general strategy for the application of pyridyl tosylates and mesylates in the Mizoroki-Heck coupling. The catalytic system also proved adaptable to changes in the heteroaromatic core as well as large-scale applications. Finally, the synthetic utility of the functionalized α-heteroarylvinyl amides was established providing straightforward access to highly functionalized heteroaromatic compounds including chiral benzylic amide derivatives.
