1174524-50-5 Usage
General Description
The chemical "(S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate" is a compound with a complex molecular structure. It is an ester formed from the reaction of (S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl alcohol and 2-methylpropanoic acid. (S)-1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate is often used in organic synthesis as a reactant or intermediate for the production of pharmaceuticals, agrochemicals, and other organic compounds. Its unique structure and reactivity make it a versatile building block for the production of various chemical compounds. Additionally, its specific stereochemistry makes it important in the synthesis of chiral compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1174524-50-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,7,4,5,2 and 4 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1174524-50:
(9*1)+(8*1)+(7*7)+(6*4)+(5*5)+(4*2)+(3*4)+(2*5)+(1*0)=145
145 % 10 = 5
So 1174524-50-5 is a valid CAS Registry Number.
1174524-50-5Relevant articles and documents
Process Development toward a Pro-Drug of R-Baclofen
Allsop, Glyn L.,Carey, John S.,Joshi, Sudhir,Leong, Paul,Mirata, Marco A.
, p. 136 - 147 (2021)
This paper describes the process development conducted toward the multi-kilogram synthesis of a novel transported pro-drug of R-baclofen. The key steps in the synthesis were the enzyme-catalyzed kinetic resolution of isopropyl(methylthiocarbonyloxy)methyl-2-methylpropionate using Candida antarctica lipase A to provide the desired (S)-enantiomer. This was followed by the reaction with sulfuryl chloride and N-hydroxysuccinimide to produce (S) 1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate. The synthesis of (S) 1-(2,5-dioxoazolidinyloxycarbonyloxy)-2-methylpropyl 2-methylpropanate enabled the efficient use of R-baclofen in the final coupling stage of the synthesis. The new route reported here is more efficient and sustainable than those reported previously and had the potential to become the commercial route of manufacture.
