1174712-58-3Relevant academic research and scientific papers
Br?nsted Acid-Catalyzed Tandem Pinacol-Type Rearrangement for the Synthesis of α-(3-Indolyl) Ketones by Using α-Hydroxy Aldehydes
Kundu, Samrat,Banerjee, Ankush,Maji, Modhu Sudan
, p. 16003 - 16012 (2019)
A Br?nsted acid-catalyzed pinacol-type rearrangement pathway is reported here to synthesize various substituted α-(3-indolyl) ketones by employing unprotected indoles and α-hydroxy aldehydes as coupling partners. Utilization of economic and readily available Br?nsted acid catalyst and use of simple starting precursors exemplify the economic viability of this method. Under this developed protocol, selective migration of aryl over alkyl or a second aryl group is observed depending upon the migratory aptitude of the substituents. Applicability of this method was further demonstrated by synthesizing highly substituted carbazoles through a simple extension of this method to one-pot cascade annulation strategy.
Br2-Catalyzed regioselective dehydrative coupling of indoles with acyloins: Direct synthesis of α-(3-indolyl) ketones
Liang, Deqiang,Li, Xiangguang,Li, Yanni,Yang, Yungang,Gao, Shulin,Cheng, Ping
, p. 29020 - 29025 (2017/07/03)
An efficient Br2-catalyzed synthesis of α-(3-indolyl) ketones via dehydrative coupling of simple indoles with acyloins is presented. This reaction proceeded with high C-3 selectivity and a wide substrate scope, and without any metal catalyst. B
N-heterocyclic carbene-catalyzed cross-coupling of aldehydes with arylsulfonyl indoles
Li, Yi,Shi, Fu-Qiang,He, Qing-Li,You, Shu-Li
supporting information; experimental part, p. 3182 - 3185 (2009/11/30)
3-(1-Arylsulfonylalkyl)indoles as electrophiles in the N-heterocyclic carbene-catalyzed umpolung reaction of aldehydes were realized for the first time. This intermolecular Stetter-type reaction features the commercially available catalyst and mild reacti
