1174764-22-7

Upstream product

• 28697-07-6 (R)-1-((benzyloxy)carbonyl)piperidine-2-carboxylic acid 
• 79069-51-5 (S)-N-tert-butoxycarbonylvalinal 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 1174764-21-6 ethyl (R)-2-{3-[(N-benzyloxycarbonyl-(R)-pipecolyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carboxylate 
• 1207472-50-1 (4S,2E)-4-(tert-butoxycarbonylamino)-5-methyl-2-hexenenitrile 
• 1174764-16-9 (4R)-4-[(tert-butoxycarbonyl)methylamino]-5-methylhexanethioamide 
• 1174764-15-8 (4R)-4-[(tert-butoxycarbonyl)methylamino]-5-methylhexanenitrile 

Downstream Products

• 1266174-40-6 C₃₆H₅₅N₅O₅S 
• 1174764-24-9 (4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-5-phenyl-pentanoic acid trifluoroacetic acid salt 
• 1219930-75-2 methyl (2S,4R)-2-methyl-4-[({2-[(3R)-4-methyl-3-{methyl[(2S,3S)-3-methyl-2-({[(2R)-1-methylpiperidin-2-yl]carbonyl}amino)pentanoyl]amino}pentyl]-1,3-thiazol-4-yl}carbonyl)amino]-5-phenylpentanoate 
• 1174764-13-6 (2S,4R)-4-[((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)-amino]-4-methyl-pentyl}-thiazole-4-carbonyl)-amino]-2-methyl-5-phenyl-pentanoic acid trifluoroacetic acid salt 
• 1207472-57-8 methyl (4R)-4-[((R)-2-{3-[(N-benzyloxycarbonyl-(R)-pipecolyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carbonyl)amino]-5-phenylpentanoate 
• 1207472-58-9 methyl (2S,4R)-4-[((R)-2-{3-[(N-benzyloxycarbonyl-(R)-pipecolyl-(S)-isoleucyl)methylamino]-4-methylpentyl}thiazole-4-carbonyl)amino]-2-methyl-5-phenylpentanoate 
• 1266207-88-8 C₄₁H₅₅N₅O₇S 
• 1266208-72-3 C₃₄H₅₁N₅O₅S 
• 1207472-60-3 ((R)-2-{3-[methyl-(N-methyl-(R)-pipecolyl-(S)-isoleucyl)amino]-4-methylpentyl}thiazole-4-carbonyl)(S)-phenylaniline trifluoroacetic acid salt 

Relevant academic research and scientific papers

BIOACTIVE PRE-TUBULYSINS AND USE THEREOF

The invention relates to bioactive pre-tubulysin derivatives, their preparation and pharmacological use.

Synthesis and biological evaluation of pretubulysin and derivatives

Pretubulysin, a biosynthetic precursor of the tubulysins, shows potent biological activity in the subnanomolar range towards various tumor cell lines. Its activity is only slightly less than those of the structurally more complex tubulysins. With a straig