117480-37-2Relevant academic research and scientific papers
Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors
Fridén-Saxin, Maria,Seifert, Tina,Landergren, Marie Rydén,Suuronen, Tiina,Lahtela-Kakkonen, Maija,Jarho, Elina M.,Luthman, Kristina
, p. 7104 - 7113 (2012)
A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized in a on
Rh(III)-Catalyzed Aldehydic C?H Functionalization Reaction between Salicylaldehydes and Sulfoxonium Ylides
Xu, Guo-Dong,Huang, Kenneth L.,Huang, Zhi-Zhen
supporting information, p. 3318 - 3323 (2019/06/25)
A novel aldehydic C?H functionalization reaction between salicylaldehydes and sulfoxonium ylides has been developed under rhodium(III) catalysis, affording coupling products in moderate to good yields. A plausible mechanism involving aldehydic C(sp2)?H activation by rhodium(III) and rhodium(III) catalyzed carbene insertion is also proposed. It was also found that the aldehydic C?H functionalization followed by dehydrative cyclization was able to produce flavonoids in one-pot. (Figure presented.).
Synthesis of 2,3,6,8-tetrasubstituted chromone scaffolds
Dahlen, Kristian,Wallen, Erik A. A.,Grotli, Morten,Luthman, Kristina
, p. 6863 - 6871 (2007/10/03)
A useful and efficient synthetic strategy to 2,3,6,8-tetrasubstituted chromone derivatives has been developed. 2-Aryl/styryl-8-bromo-6-chloro-3- hydroxychromone derivatives were synthesized and used as scaffolds by introducing a variety of substituents in
A scaffold approach to 3,6,8-trisubstituted flavones
Dahlén, Kristian,Gr?tli, Morten,Luthman, Kristina
, p. 897 - 900 (2007/10/03)
An efficient synthetic approach to 3,6,8-trisubstituted flavone scaffolds has been developed based on Pd-mediated coupling reactions. Georg Thieme Verlag Stuttgart.
