Journal of Medicinal Chemistry p. 7104 - 7113 (2012)
Update date:2022-07-29
Topics:
Fridén-Saxin, Maria
Seifert, Tina
Landergren, Marie Rydén
Suuronen, Tiina
Lahtela-Kakkonen, Maija
Jarho, Elina M.
Luthman, Kristina
A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized in a on
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