117487-10-2Relevant academic research and scientific papers
Multicomponent synthesis of unnatural pyrrolizidines using 1,3-dipolar cycloaddition of proline esters
Mancebo-Aracil, Juan,Najera, Carmen,Sansano, Jose M.
, p. 11218 - 11220 (2013)
The synthesis of unnatural pyrrolizidines has been studied using a multicomponent-domino process involving proline or 4-hydroxyproline esters, an aldehyde and a dipolarophile. The formation of the iminium salt promotes the 1,3-dipolar cycloaddition affording highly substituted pyrrolizidines under mild conditions and high regio- and diastereoselectivities.
1,3 - Dipolar cyclo addition reactions of azomethine ylides generated in situ throught condensation of secondary α-amino esters with benzaldehyde
Joucla, Marc,Mortier, Jacques,Hamelin, Jack,Toupet, Loic
, p. 143 - 150 (2007/10/02)
1,3-Dipolar cycloaddition reactions to alkenes and carbonyl compounds have been performed from in situ generated azomethine ylides through condensation of secondary α-amino esters with benzaldehyde.The stereochemistry of the cycloadducts was determined fr
