1174895-53-4

Basic information

• Product Name: 2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)pyridine
• Synonyms: 2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)pyridine
• CAS NO: 1174895-53-4
• Molecular Weight: 299.295
• Mol File: 1174895-53-4.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)pyridine(1174895-53-4)
• EPA Substance Registry System: 2-(4′-(trifluoromethyl)-[1,1′-biphenyl]-2-yl)pyridine(1174895-53-4)

Safety Data

• Hazardous Substances Data: 1174895-53-4(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 109-04-6 2-bromo-pyridine 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 5957-89-1 2-(2-methoxy-phenyl)-pyridine 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 1236046-47-1 (2-(pyridin-2’-yl)phenyl)(4-(trifluoromethyl)phenyl)methanone 
• 1008-89-5 2-phenylpyridine 
• 1240390-02-6 hydroxy[4-(trifluoromethyl)phenyl]-λ³-iodaneyl 4-methylbenzenesulfonate 
• 35692-32-1 trimethoxy(4-(trifluoromethyl)phenyl)silane 
• 35692-27-4 triethoxy(4-methoxyphenyl)silane 
• 98-80-6 phenylboronic acid 
• 98-56-6 4-chlorobenzotrifluoride 
• 17997-47-6 2-tri-n-butylstannylpyridine 
• 89346-48-5 2-(2-fluorophenyl)pyridine 

Relevant articles and documents

Ruthenium(II)-catalyzed ortho-C-H arylation of diverse N-heterocycles with aryl silanes by exploiting solvent-controlled N-coordination

We report the first method for the direct, regioselective Ru(ii)-catalyzed oxidative arylation of C-H bonds in diverse N-heterocycles with aryl silanes by exploiting solvent-controlled N-coordination. The reaction takes advantage of the attractive feature

Directing Group-Promoted Inert C?O Bond Activation Using Versatile Boronic Acid as a Coupling Agent

A simple Ni(cod)2 and carbene mediated strategy facilitates the efficient catalytic cross-coupling of methoxyarenes with a variety of organoboron reagents. Directing groups facilitate the activation of inert C?O bonds in under-utilized aryl methyl ethers enabling their adaptation for C?C cross-coupling reactions as less toxic surrogates to the ubiquitous haloarenes. The method reported enables C?C cross-coupling with readily available and economical arylboronic acid reagents, which is unprecedented, and compares well with other organoboron reagents with similarly high reactivity. Extension to directing group assisted chemo-selective C?O bond cleavage, and further application towards the synthesis of novel bifunctionalized biaryls is reported. Key to the success of this protocol is the use of directing groups proximal to the reaction center to facilitate the activation of the inert C?OMe bond.

Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents

A new and operationally simple approach for palladium-catalyzed C-H functionalization reactions utilizing an organophosphorus/sulfonate hypervalent iodine reagent as both an oxidant and the source of a functional group has been developed. Through this method, the oxidative phosphorylation-, sulfonation-, and hydroxylation of unactivated benzyl C(sp3)-H bonds, along with the hydroxylation and arylation of aryl C(sp2)-H bonds, are successfully realized under mild conditions and with excellent site-selectivity. The versatile C-OSO2R bond provides a platform for a wide array of subsequent diversification reactions.